Endothelin and Its Inhibitors

Mitarbeit:Warner, Timothy D.

• Gebundenes Buch

Produktbeschreibung

Recent publications have addressed specific aspects of the endothelins, such as their roles in disease or the importance of endothelin receptors. However, in this book the entire field of endothelins is covered. This includes the pathways of endothelin production and their regulation, the local and systemic actions of endothelins, receptors for the endothelins and the signalling pathways employed, and the involvement of endothelins in a range of diseases. Attention is also paid to the development through chemistry, pharmacology and toxicology of endothelin antagonists and endothelin-converting enzyme inhibitors, with mention of all the important members of these drug classes. This leads to well-rounded discussions of the potential therapeutic benefit of endothelin inhibitors.

Produktdetails

• Handbook of Experimental Pharmacology 152
• Verlag: Springer, Berlin
• Seitenzahl: 532
• Englisch
• Abmessung: 245mm
• Gewicht: 922g
• ISBN-13: 9783540679851
• ISBN-10: 3540679855
• Artikelnr.: 09592821

Inhaltsangabe

Form the contents:
From the contents: Historical Perspective and Introduction
- Sarafotoxins
- Endothelin-Converting Enzymes
- Endothelin Receptors
- Cell Signalling by Endothelin Peptides
- Gene Deletion of Endothelin Systems
- Endothelin-Converting Enzyme Inhibitors
- Endothelin-Converting Enzymes and Endothelin Receptor Localisation in Human Tissues
- Endothelin Receptor Antagonists
- Toxicology of Endothelin Antagonists
- Release of Autacoids
- The Roles of Endothelins in Proliferation, Apoptosis and Angiogenesis
- Endothelins in Cerebral Vasospasms and Strokes
- Airway Reactivity and Disease
- Endothelin-1 and Pulmonary Hypertension
- Vascular and Cardiac Effects
- Liver and Gastrointestinal System
- Endothelins and the Kidney
- Endothelin Ligands and Their Experimental Effects Within the Human Circulation.