George A. Brooks, Kenneth M. Baldwin, Thomas D. Fahey
Exercise Physiology
Human Bioenergetics and Its Applications
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George A. Brooks, Kenneth M. Baldwin, Thomas D. Fahey
Exercise Physiology
Human Bioenergetics and Its Applications
- Broschiertes Buch
The essential text for graduate students studying exercise physiology. Exercise Physiology: Human Bioenergetics and Its Applications, Sixth Edition, provides advanced exercise physiology students with the high-level background information needed to excel in the field of exercise physiology. With guidance from expert authors at the forefront of exercise physiology, explore the interrelationship of exercise, metabolism, and energy storage. With special attention devoted to revisions that add clarity and consistency throughout the text, the sixth edition also contains a wealth of other updates: *…mehr
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The essential text for graduate students studying exercise physiology. Exercise Physiology: Human Bioenergetics and Its Applications, Sixth Edition, provides advanced exercise physiology students with the high-level background information needed to excel in the field of exercise physiology. With guidance from expert authors at the forefront of exercise physiology, explore the interrelationship of exercise, metabolism, and energy storage. With special attention devoted to revisions that add clarity and consistency throughout the text, the sixth edition also contains a wealth of other updates: * More information on the lactate shuttle theory—from lead author George Brooks, the developer of the concept * Updated content covering metaboreflex, lipid metabolism, and pulmonary ventilation * Expanded discussion of the control of gene expression of muscle protein * New content on diseases and guidelines on prevention and management * Updated information on metabolite homeostasis Often referred to as the "bible of the field," Exercise Physiology: Human Bioenergetics and Its Applications unpacks the principles of bioenergetics, taking readers through the mechanisms of performance as determined by physical and chemical factors. The evolution of exercise physiology as a field is traced back through history, framing present-day breakthroughs through the lens of historical practices. Readers will investigate the capabilities and limits of human physical function, examining exercise not just from a high-performance perspective but also in terms of health benefits. The text has added pedagogical learning aids that make engaging with the content easier, such as chapter objectives, chapter summaries, and review questions. Original figures and tables from the authors encourage critical thinking and help with the practical application of concepts in the book. Students can rest assured that they are learning from legends with the sixth edition of Exercise Physiology: Human Bioenergetics and Its Applications. With updated content and new breakthroughs, as well as the book's reputation as a must-use resource, this text is the best choice for graduate students in exercise physiology.
Produktdetails
- Produktdetails
- Verlag: Human Kinetics Publishers
- Sixth Edition
- Seitenzahl: 800
- Erscheinungstermin: 13. März 2026
- Englisch
- Abmessung: 279mm x 216mm
- ISBN-13: 9781718235823
- ISBN-10: 1718235828
- Artikelnr.: 75621587
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- gpsr@libri.de
- Verlag: Human Kinetics Publishers
- Sixth Edition
- Seitenzahl: 800
- Erscheinungstermin: 13. März 2026
- Englisch
- Abmessung: 279mm x 216mm
- ISBN-13: 9781718235823
- ISBN-10: 1718235828
- Artikelnr.: 75621587
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- gpsr@libri.de
George A. Brooks, PhD, is best known for developing the lactate shuttle theory and identifying the role of the mitochondrial reticulum in metabolism. He is a distinguished professor of integrative biology at University of California, Berkeley, where he has been teaching since 1971. He is a fellow of the American Physiological Society (APS), the American College of Sports Medicine (ACSM), and the European College of Sport Science (ECSS). Brooks was awarded the Walter B. Cannon Award lectureship in 2025 for his groundbreaking research. He was the keynote speaker at the 2025 American Physiology Summit. He has also earned the Honor Award designation from both the American College of Sports Medicine (2007) and the American Physiological Society's Exercise and Environmental Physiology Section (2014). Thomas Fahey, EdD, is a professor emeritus of California State University, Chico, where he received the Outstanding Professor Award. An avid masters track and field discus athlete, he was awarded a Lifetime Achievement Award/Lad Pataki Award (2018) as well as an Outstanding Masters Field Athlete (2008) from USA Track and Field. He retired from teaching in 2018 but not before working at UC Berkeley, Stanford University, and other institutions, including California State University, Chico, where he finalized his 50-year teaching career. He has continued to stay abreast of the research in the field and has authored or coauthored over 33 books. He has also written two personal trainer courses. Fahey was honored to be the doping control director for soccer at the Stanford venue for the 1984 Olympic Games in Los Angeles. A familiar face within the athletic community, Fahey was the 1998 Master's National and World discus champion, and he is a four-time gold medalist at the World Masters Games. He earned medals in five consecutive world championships (spanning 20 years) and secured 11 straight national titles. Kenneth Baldwin, PhD, completed his doctorate in exercise physiology in 1970 under Charles Tipton at the University of Iowa. He finished postdoctoral training under John Holloszy at the Washington University School of Medicine in St. Louis. His research interests focused on exercise-induced biochemical and functional adaptations in heart and skeletal muscle. As one of the first faculty members recruited to the University of California, Irvine (UCI) School of Medicine, he played an important role in shaping the teaching, research and governance of the school, known in the beginning as the California College of Medicine. He served as senior associate dean for academic affairs from 1989 to 1996. He served on the Space Studies Board of the National Academy of Sciences, overseeing research for animals and humans in space. He also organized a 2018 symposium for the National Academy of Sciences at their headquarters in Washington, D.C., to consider the formidable physiological challenges for space travel to and from Mars. He was honored by Springfield College with their Distinguished Alumnus award in 2016. He also received the American Physiological Society's Living History Award and UCI's Outstanding Emeritus Award in 2019. Regrettably, Dr. Baldwin passed away in October 2023.
Part I. Energy Systems
Chapter 1. Introduction
History of Exercise Physiology
Rate-Limiting Factors
Maximal Oxygen Consumption
Performance and Predictors of Performance
Stress and Strain
Overload Principle
Professional Field of Exercise Physiology and Exercise and Sports Science
Physical Activity and Health: Reports, Guidelines, and Recommendations
Chapter 2. Bioenergetics
Heat, Temperature, and Biological Systems
Laws of Thermodynamics
Adenosine Triphosphate
Chapter 3. ATP Homeostasis
Nonoxidative Immediate Energy System
Nonoxidative Glycolytic and Glycogenolytic Energy Systems
Oxidative Energy System
Energy Systems and Performance
Enzymatic Regulation of Metabolism
Adenylate Energy Charge
Energy Supply and Use During Physical Exercise Within the Context of Energy
Flow in the Biosphere
Chapter 4. Basics of Metabolism
Energy Transduction in the Biosphere
Metabolism and Heat Production in Animals
Early Attempts at Calorimetry
Open-Circuit Calorimeters
Respiratory Gas Exchange Ratio
Indirect Calorimetry
Chapter 5. Glycolysis and Glycogenolysis
Glycolysis
Dietary Sources of Glucose
Postprandial Lactate Shuttle
Blood Glucose Concentration During Rest and Exercise
Glycolysis in History
Glycogenolysis
Cell–Cell Lactate Shuttle
Gluconeogenesis
Effects of Training on Glycolytic Enzyme Abundances and Glycolysis
Glucose, Glycogen, and Other Substrate Use During Exercise
Effects of Exercise and Endurance Training on Blood Lactate
Chapter 6. Cellular Oxidation of Pyruvate and Lactate
Structure of the Mitochondrial Reticulum
Connectivity of the Mitochondrial Reticulum
Krebs Cycle
Electron Transport Chain
Effects of Training on Skeletal Muscle Mitochondrial Protein
Training Adaptations and Coordination of Mitochondrial and Nuclear Genes
Muscle Mitochondrial Oxygen Partial Pressure During Exercise
Free Radicals, Reactive Oxygen Species, and Oxidative Damage
Chapter 7. Lipid Metabolism
Lipid Structure
Esterification and Hydrolysis
Dietary Lipids
Free Fatty Acid Blood Levels
Intramuscular Triglycerides and Lipoproteins as Fuel Sources
Exercise Recovery and Lipid Oxidation Timing
Mitochondrial Adaptation to Enhance Fat Oxidation
Glucose–Fatty Acid (Randle) Cycle
Crossover Concept
Energy Substrate Shunting and Shuttling During Exercise
Ketones as Fuels
Chapter 8. Protein and Amino Acid Metabolism
Amino Acid and Protein Structure
Dietary Proteins
Amino Acid Pools
Gluconeogenic Amino Acids
Branched-Chain Amino Acids
Glucose-Alanine Cycle
Glutamate and Glutamine as Ammonia Scavengers
Proteomics, Metabolomics, and Fluxomics
Chapter 9. Neuroendocrine Control of Metabolism
Hormonal Control of Glycemia
Hepatic Control of Glycemia
Autonomic Nervous System and Catecholamine Control of Glycemia
Endocrine Control of Gluconeogenesis
Chapter 10. Metabolic Response to Exercise
Validity of Indirect Calorimetry in Measuring Exercise Responses
Principles of Tracer Methodology
Muscle as a Consumer of Lactate During Exercise
Excess Postexercise Oxygen Consumption (EPOC), or the O2 Debt
Historical O2 Debt Theory
Metabolic Fate of Lactate After Exercise
Exercise-Related Disturbances to Mitochondrial Function
Lactate Turnover During Exercise
Part II. Physiological Systems
Chapter 11. Pulmonary Ventilation
Breathing, Ventilation, and Respiration
Environmental Influences on Pulmonary Gas Volumes
Entry of O2 Into Blood
Pulmonary Diffusion
Red Blood Cells and Hemoglobin in CO2 Transport
Bicarbonate Buffer System
Chapter 12. Mechanics of Pulmonary Ventilation
Pulmonary Anatomy
Partial Pressures
Control of Tidal Volume and Breathing Frequency
Neural-Humoral Control of Ventilation
Chapter 13. Ventilation as a Limiting Factor
Ventilatory Perfusion Ratio (VE/Q)
Ventilatory Equivalent of Oxygen (VE/VO2) During Exercise
Maximum Expiratory Minute Ventilation Versus Maximum Voluntary Ventilation
Partial Pressures of Alveolar and Arterial Oxygen
Alveolar Surface Area for Gas Exchange
Fatigue of Ventilatory Muscles and Other Limitations
Pulmonary Limitations in Highly Trained Athletes
Chapter 14. Mechanics of the Heart
Structure of the Heart
Regulation of Cardiac Chronotropy and Inotropy
Myocardium Electrical Activity and Measurement
Cardiac Performance at Rest and During Exercise
Chapter 15. Circulation and Its Control
Mechanics of Circulation
Determinants of Blood Flow
Neural Control of the Heart
Neural Control of the Cardiovascular System
Hormonal Control Mechanisms
Metabolic Regulation of Blood Flow
Autoregulation
Cardiovascular Control During Exercise
Redistribution (Shunting) of Blood Flow During Exercise and Other Forms of
Cell Work
Chapter 16. Cardiovascular Dynamics and Exercise
Cardiovascular Responses to Exercise
Limits of Cardiovascular Performance
Changes in Cardiovascular Parameters With Training
Chapter 17. Skeletal Muscle Structure and Contractile Properties
Structure of Skeletal Muscle
Steric Block Model
Crossbridge Cycle Models
Length–Tension Relationship
Isometric Contractions
Force–Velocity Relationship
Chapter 18. Nervous System Control of Movement
Structure of the Nervous System
Excitability of Neurons
Neuromuscular Transmission
Excitation–Contraction Coupling
Muscle Fibers and Motor Unit Recruitment
Integrative Control of Movement
Motor Control Process
Part III. Adaptations to Exercise and Environment
Chapter 19. Principles of Skeletal Muscle Adaptations
Myoplasticity
Muscle Fiber Types in Elite Athletes
Muscle Adaptations in Response to Endurance Training
Muscle Adaptations in Response to Resistance Training
Muscle Adaptations in Response to Decreased Physical Activity
Muscle Adaptations in Response to Injury
Sex Differences in Skeletal Muscle
Age-Associated Changes in Skeletal Muscle
Chapter 20. Muscle Strength, Power, and Flexibility
Classification of Strength Exercises
Muscle Adaptation to Progressive Resistance Exercise
Components of Muscle Strength
Delayed Onset Muscle Soreness
Progressive Resistance Training Programs
Flexibility Training
Chapter 21. Endurance Training Principles
Historical Perspective
Human Genotypes and Phenotypes
Overload, Stimulus, and Response
Three Components of a Training Session
Specificity, Skill Acquisition, and Developing Metabolism
Over-Distance Training
Interval Training
Training Variation and Peaking
Volume Versus Intensity of Training
Peripheral Versus Central Limitations
High-Altitude Training
Methods of Evaluating Training Intensity
Planning a Training Schedule
Chapter 22. Temperature Regulation and Exercise in Heat and Cold
Normal Body Temperature
Heat Transfer
Heat Production Mechanisms
Heat Loss Mechanisms
Temperature Regulation and the Hypothalamus
Exercise in the Cold
Exercise in the Heat
Thermal Stress and Heat-Related Illnesses During Exercise
Chapter 23. Atmospheric Pressure, Air Pollution, Travel, Space, and
Exercise
Altitude
Hyperbaria
Biological Rhythms and Travel Across Time Zones
Air Pollution
Space Physiology
Part IV. Exercise and Performance Factors
Chapter 24. Exercise Testing and Prescription
Medical Screening Before Beginning an Exercise Program
Understanding METs and MET-Minutes
Maximum Oxygen Consumption and Functional Capacity
Measuring Maximum Oxygen Consumption
Tests of Functional Capacity
VO2max Field Tests
Health Benefits of Physical Activity
Chapter 25. Cardiovascular Diseases
Sudden Cardiac Death and Exercise
Atherosclerosis Development
Lipoproteins
Hypertension
Heart Failure
Coronary Artery Disease Risk Factors
Cardiac Rehabilitation
Chapter 26. Obesity and Body Composition
Body Composition
Obesity and Health
Energy Balance
Obesity Treatment
Chapter 27. Disease and Disability
Chronic Diseases
Pulmonary Disorders
Immunity and Infection
Mental Health Disorders
Physical Disabilities
Bed Rest and Deconditioning
Chapter 28. Nutrition and Athletic Performance
Nutritional Practice in Athletics
Macronutrient Reports
Muscle and Dietary Carbohydrate
Amino Acid Role in Exercise
Lean Tissue Maintenance and Accretion
Fat Utilization During Exercise
Precompetition Meals
Fluid, Energy, and Electrolyte Ingestion During and After Exercise
Balanced Diet
Special Dietary Needs and Supplements
Chapter 29. Ergogenic Aids
Banned Substances
Hormonal Ergogenic Aids
Stimulants
Nutritional Ergogenic Aids and Supplements
Blood Manipulation
Gene Doping
Chapter 30. Sex and Gender Considerations
Physiological Sex Differences
Exercise and the Menstrual Cycle
The Female Athlete Triad
Exercise and Pregnancy
Chapter 31. Growth and Development
The Growth Process in Humans
Neuroendocrine Control of Growth
Exercise, Sports, and Growth
Skeletal Development During Growth
Body Composition Changes During Growth
Changes in Cardioventilatory and Metabolic Function
Developmental Responses to Training
Chapter 32. Aging
Aging Effects and Mortality
Cardiovascular Capacity
Pulmonary Function
Bone Density
Joint Health
Skeletal Muscle
Body Composition and Stature
Neural Function
Aging Theories and Exercise Effects
Exercise Prescription for Older Adults
Chapter 33. Fatigue and the Limits of Performance
Identifying Fatigue
Metabolite Depletion
Metabolite Accumulation
Oxygen Depletion and Muscle Mitochondrial Density
Central and Neuromuscular Fatigue
Psychological Fatigue
Heart Muscle Fatigue
VO2max and Endurance
Fatigue Research Technology
Chapter 1. Introduction
History of Exercise Physiology
Rate-Limiting Factors
Maximal Oxygen Consumption
Performance and Predictors of Performance
Stress and Strain
Overload Principle
Professional Field of Exercise Physiology and Exercise and Sports Science
Physical Activity and Health: Reports, Guidelines, and Recommendations
Chapter 2. Bioenergetics
Heat, Temperature, and Biological Systems
Laws of Thermodynamics
Adenosine Triphosphate
Chapter 3. ATP Homeostasis
Nonoxidative Immediate Energy System
Nonoxidative Glycolytic and Glycogenolytic Energy Systems
Oxidative Energy System
Energy Systems and Performance
Enzymatic Regulation of Metabolism
Adenylate Energy Charge
Energy Supply and Use During Physical Exercise Within the Context of Energy
Flow in the Biosphere
Chapter 4. Basics of Metabolism
Energy Transduction in the Biosphere
Metabolism and Heat Production in Animals
Early Attempts at Calorimetry
Open-Circuit Calorimeters
Respiratory Gas Exchange Ratio
Indirect Calorimetry
Chapter 5. Glycolysis and Glycogenolysis
Glycolysis
Dietary Sources of Glucose
Postprandial Lactate Shuttle
Blood Glucose Concentration During Rest and Exercise
Glycolysis in History
Glycogenolysis
Cell–Cell Lactate Shuttle
Gluconeogenesis
Effects of Training on Glycolytic Enzyme Abundances and Glycolysis
Glucose, Glycogen, and Other Substrate Use During Exercise
Effects of Exercise and Endurance Training on Blood Lactate
Chapter 6. Cellular Oxidation of Pyruvate and Lactate
Structure of the Mitochondrial Reticulum
Connectivity of the Mitochondrial Reticulum
Krebs Cycle
Electron Transport Chain
Effects of Training on Skeletal Muscle Mitochondrial Protein
Training Adaptations and Coordination of Mitochondrial and Nuclear Genes
Muscle Mitochondrial Oxygen Partial Pressure During Exercise
Free Radicals, Reactive Oxygen Species, and Oxidative Damage
Chapter 7. Lipid Metabolism
Lipid Structure
Esterification and Hydrolysis
Dietary Lipids
Free Fatty Acid Blood Levels
Intramuscular Triglycerides and Lipoproteins as Fuel Sources
Exercise Recovery and Lipid Oxidation Timing
Mitochondrial Adaptation to Enhance Fat Oxidation
Glucose–Fatty Acid (Randle) Cycle
Crossover Concept
Energy Substrate Shunting and Shuttling During Exercise
Ketones as Fuels
Chapter 8. Protein and Amino Acid Metabolism
Amino Acid and Protein Structure
Dietary Proteins
Amino Acid Pools
Gluconeogenic Amino Acids
Branched-Chain Amino Acids
Glucose-Alanine Cycle
Glutamate and Glutamine as Ammonia Scavengers
Proteomics, Metabolomics, and Fluxomics
Chapter 9. Neuroendocrine Control of Metabolism
Hormonal Control of Glycemia
Hepatic Control of Glycemia
Autonomic Nervous System and Catecholamine Control of Glycemia
Endocrine Control of Gluconeogenesis
Chapter 10. Metabolic Response to Exercise
Validity of Indirect Calorimetry in Measuring Exercise Responses
Principles of Tracer Methodology
Muscle as a Consumer of Lactate During Exercise
Excess Postexercise Oxygen Consumption (EPOC), or the O2 Debt
Historical O2 Debt Theory
Metabolic Fate of Lactate After Exercise
Exercise-Related Disturbances to Mitochondrial Function
Lactate Turnover During Exercise
Part II. Physiological Systems
Chapter 11. Pulmonary Ventilation
Breathing, Ventilation, and Respiration
Environmental Influences on Pulmonary Gas Volumes
Entry of O2 Into Blood
Pulmonary Diffusion
Red Blood Cells and Hemoglobin in CO2 Transport
Bicarbonate Buffer System
Chapter 12. Mechanics of Pulmonary Ventilation
Pulmonary Anatomy
Partial Pressures
Control of Tidal Volume and Breathing Frequency
Neural-Humoral Control of Ventilation
Chapter 13. Ventilation as a Limiting Factor
Ventilatory Perfusion Ratio (VE/Q)
Ventilatory Equivalent of Oxygen (VE/VO2) During Exercise
Maximum Expiratory Minute Ventilation Versus Maximum Voluntary Ventilation
Partial Pressures of Alveolar and Arterial Oxygen
Alveolar Surface Area for Gas Exchange
Fatigue of Ventilatory Muscles and Other Limitations
Pulmonary Limitations in Highly Trained Athletes
Chapter 14. Mechanics of the Heart
Structure of the Heart
Regulation of Cardiac Chronotropy and Inotropy
Myocardium Electrical Activity and Measurement
Cardiac Performance at Rest and During Exercise
Chapter 15. Circulation and Its Control
Mechanics of Circulation
Determinants of Blood Flow
Neural Control of the Heart
Neural Control of the Cardiovascular System
Hormonal Control Mechanisms
Metabolic Regulation of Blood Flow
Autoregulation
Cardiovascular Control During Exercise
Redistribution (Shunting) of Blood Flow During Exercise and Other Forms of
Cell Work
Chapter 16. Cardiovascular Dynamics and Exercise
Cardiovascular Responses to Exercise
Limits of Cardiovascular Performance
Changes in Cardiovascular Parameters With Training
Chapter 17. Skeletal Muscle Structure and Contractile Properties
Structure of Skeletal Muscle
Steric Block Model
Crossbridge Cycle Models
Length–Tension Relationship
Isometric Contractions
Force–Velocity Relationship
Chapter 18. Nervous System Control of Movement
Structure of the Nervous System
Excitability of Neurons
Neuromuscular Transmission
Excitation–Contraction Coupling
Muscle Fibers and Motor Unit Recruitment
Integrative Control of Movement
Motor Control Process
Part III. Adaptations to Exercise and Environment
Chapter 19. Principles of Skeletal Muscle Adaptations
Myoplasticity
Muscle Fiber Types in Elite Athletes
Muscle Adaptations in Response to Endurance Training
Muscle Adaptations in Response to Resistance Training
Muscle Adaptations in Response to Decreased Physical Activity
Muscle Adaptations in Response to Injury
Sex Differences in Skeletal Muscle
Age-Associated Changes in Skeletal Muscle
Chapter 20. Muscle Strength, Power, and Flexibility
Classification of Strength Exercises
Muscle Adaptation to Progressive Resistance Exercise
Components of Muscle Strength
Delayed Onset Muscle Soreness
Progressive Resistance Training Programs
Flexibility Training
Chapter 21. Endurance Training Principles
Historical Perspective
Human Genotypes and Phenotypes
Overload, Stimulus, and Response
Three Components of a Training Session
Specificity, Skill Acquisition, and Developing Metabolism
Over-Distance Training
Interval Training
Training Variation and Peaking
Volume Versus Intensity of Training
Peripheral Versus Central Limitations
High-Altitude Training
Methods of Evaluating Training Intensity
Planning a Training Schedule
Chapter 22. Temperature Regulation and Exercise in Heat and Cold
Normal Body Temperature
Heat Transfer
Heat Production Mechanisms
Heat Loss Mechanisms
Temperature Regulation and the Hypothalamus
Exercise in the Cold
Exercise in the Heat
Thermal Stress and Heat-Related Illnesses During Exercise
Chapter 23. Atmospheric Pressure, Air Pollution, Travel, Space, and
Exercise
Altitude
Hyperbaria
Biological Rhythms and Travel Across Time Zones
Air Pollution
Space Physiology
Part IV. Exercise and Performance Factors
Chapter 24. Exercise Testing and Prescription
Medical Screening Before Beginning an Exercise Program
Understanding METs and MET-Minutes
Maximum Oxygen Consumption and Functional Capacity
Measuring Maximum Oxygen Consumption
Tests of Functional Capacity
VO2max Field Tests
Health Benefits of Physical Activity
Chapter 25. Cardiovascular Diseases
Sudden Cardiac Death and Exercise
Atherosclerosis Development
Lipoproteins
Hypertension
Heart Failure
Coronary Artery Disease Risk Factors
Cardiac Rehabilitation
Chapter 26. Obesity and Body Composition
Body Composition
Obesity and Health
Energy Balance
Obesity Treatment
Chapter 27. Disease and Disability
Chronic Diseases
Pulmonary Disorders
Immunity and Infection
Mental Health Disorders
Physical Disabilities
Bed Rest and Deconditioning
Chapter 28. Nutrition and Athletic Performance
Nutritional Practice in Athletics
Macronutrient Reports
Muscle and Dietary Carbohydrate
Amino Acid Role in Exercise
Lean Tissue Maintenance and Accretion
Fat Utilization During Exercise
Precompetition Meals
Fluid, Energy, and Electrolyte Ingestion During and After Exercise
Balanced Diet
Special Dietary Needs and Supplements
Chapter 29. Ergogenic Aids
Banned Substances
Hormonal Ergogenic Aids
Stimulants
Nutritional Ergogenic Aids and Supplements
Blood Manipulation
Gene Doping
Chapter 30. Sex and Gender Considerations
Physiological Sex Differences
Exercise and the Menstrual Cycle
The Female Athlete Triad
Exercise and Pregnancy
Chapter 31. Growth and Development
The Growth Process in Humans
Neuroendocrine Control of Growth
Exercise, Sports, and Growth
Skeletal Development During Growth
Body Composition Changes During Growth
Changes in Cardioventilatory and Metabolic Function
Developmental Responses to Training
Chapter 32. Aging
Aging Effects and Mortality
Cardiovascular Capacity
Pulmonary Function
Bone Density
Joint Health
Skeletal Muscle
Body Composition and Stature
Neural Function
Aging Theories and Exercise Effects
Exercise Prescription for Older Adults
Chapter 33. Fatigue and the Limits of Performance
Identifying Fatigue
Metabolite Depletion
Metabolite Accumulation
Oxygen Depletion and Muscle Mitochondrial Density
Central and Neuromuscular Fatigue
Psychological Fatigue
Heart Muscle Fatigue
VO2max and Endurance
Fatigue Research Technology
Part I. Energy Systems
Chapter 1. Introduction
History of Exercise Physiology
Rate-Limiting Factors
Maximal Oxygen Consumption
Performance and Predictors of Performance
Stress and Strain
Overload Principle
Professional Field of Exercise Physiology and Exercise and Sports Science
Physical Activity and Health: Reports, Guidelines, and Recommendations
Chapter 2. Bioenergetics
Heat, Temperature, and Biological Systems
Laws of Thermodynamics
Adenosine Triphosphate
Chapter 3. ATP Homeostasis
Nonoxidative Immediate Energy System
Nonoxidative Glycolytic and Glycogenolytic Energy Systems
Oxidative Energy System
Energy Systems and Performance
Enzymatic Regulation of Metabolism
Adenylate Energy Charge
Energy Supply and Use During Physical Exercise Within the Context of Energy
Flow in the Biosphere
Chapter 4. Basics of Metabolism
Energy Transduction in the Biosphere
Metabolism and Heat Production in Animals
Early Attempts at Calorimetry
Open-Circuit Calorimeters
Respiratory Gas Exchange Ratio
Indirect Calorimetry
Chapter 5. Glycolysis and Glycogenolysis
Glycolysis
Dietary Sources of Glucose
Postprandial Lactate Shuttle
Blood Glucose Concentration During Rest and Exercise
Glycolysis in History
Glycogenolysis
Cell–Cell Lactate Shuttle
Gluconeogenesis
Effects of Training on Glycolytic Enzyme Abundances and Glycolysis
Glucose, Glycogen, and Other Substrate Use During Exercise
Effects of Exercise and Endurance Training on Blood Lactate
Chapter 6. Cellular Oxidation of Pyruvate and Lactate
Structure of the Mitochondrial Reticulum
Connectivity of the Mitochondrial Reticulum
Krebs Cycle
Electron Transport Chain
Effects of Training on Skeletal Muscle Mitochondrial Protein
Training Adaptations and Coordination of Mitochondrial and Nuclear Genes
Muscle Mitochondrial Oxygen Partial Pressure During Exercise
Free Radicals, Reactive Oxygen Species, and Oxidative Damage
Chapter 7. Lipid Metabolism
Lipid Structure
Esterification and Hydrolysis
Dietary Lipids
Free Fatty Acid Blood Levels
Intramuscular Triglycerides and Lipoproteins as Fuel Sources
Exercise Recovery and Lipid Oxidation Timing
Mitochondrial Adaptation to Enhance Fat Oxidation
Glucose–Fatty Acid (Randle) Cycle
Crossover Concept
Energy Substrate Shunting and Shuttling During Exercise
Ketones as Fuels
Chapter 8. Protein and Amino Acid Metabolism
Amino Acid and Protein Structure
Dietary Proteins
Amino Acid Pools
Gluconeogenic Amino Acids
Branched-Chain Amino Acids
Glucose-Alanine Cycle
Glutamate and Glutamine as Ammonia Scavengers
Proteomics, Metabolomics, and Fluxomics
Chapter 9. Neuroendocrine Control of Metabolism
Hormonal Control of Glycemia
Hepatic Control of Glycemia
Autonomic Nervous System and Catecholamine Control of Glycemia
Endocrine Control of Gluconeogenesis
Chapter 10. Metabolic Response to Exercise
Validity of Indirect Calorimetry in Measuring Exercise Responses
Principles of Tracer Methodology
Muscle as a Consumer of Lactate During Exercise
Excess Postexercise Oxygen Consumption (EPOC), or the O2 Debt
Historical O2 Debt Theory
Metabolic Fate of Lactate After Exercise
Exercise-Related Disturbances to Mitochondrial Function
Lactate Turnover During Exercise
Part II. Physiological Systems
Chapter 11. Pulmonary Ventilation
Breathing, Ventilation, and Respiration
Environmental Influences on Pulmonary Gas Volumes
Entry of O2 Into Blood
Pulmonary Diffusion
Red Blood Cells and Hemoglobin in CO2 Transport
Bicarbonate Buffer System
Chapter 12. Mechanics of Pulmonary Ventilation
Pulmonary Anatomy
Partial Pressures
Control of Tidal Volume and Breathing Frequency
Neural-Humoral Control of Ventilation
Chapter 13. Ventilation as a Limiting Factor
Ventilatory Perfusion Ratio (VE/Q)
Ventilatory Equivalent of Oxygen (VE/VO2) During Exercise
Maximum Expiratory Minute Ventilation Versus Maximum Voluntary Ventilation
Partial Pressures of Alveolar and Arterial Oxygen
Alveolar Surface Area for Gas Exchange
Fatigue of Ventilatory Muscles and Other Limitations
Pulmonary Limitations in Highly Trained Athletes
Chapter 14. Mechanics of the Heart
Structure of the Heart
Regulation of Cardiac Chronotropy and Inotropy
Myocardium Electrical Activity and Measurement
Cardiac Performance at Rest and During Exercise
Chapter 15. Circulation and Its Control
Mechanics of Circulation
Determinants of Blood Flow
Neural Control of the Heart
Neural Control of the Cardiovascular System
Hormonal Control Mechanisms
Metabolic Regulation of Blood Flow
Autoregulation
Cardiovascular Control During Exercise
Redistribution (Shunting) of Blood Flow During Exercise and Other Forms of
Cell Work
Chapter 16. Cardiovascular Dynamics and Exercise
Cardiovascular Responses to Exercise
Limits of Cardiovascular Performance
Changes in Cardiovascular Parameters With Training
Chapter 17. Skeletal Muscle Structure and Contractile Properties
Structure of Skeletal Muscle
Steric Block Model
Crossbridge Cycle Models
Length–Tension Relationship
Isometric Contractions
Force–Velocity Relationship
Chapter 18. Nervous System Control of Movement
Structure of the Nervous System
Excitability of Neurons
Neuromuscular Transmission
Excitation–Contraction Coupling
Muscle Fibers and Motor Unit Recruitment
Integrative Control of Movement
Motor Control Process
Part III. Adaptations to Exercise and Environment
Chapter 19. Principles of Skeletal Muscle Adaptations
Myoplasticity
Muscle Fiber Types in Elite Athletes
Muscle Adaptations in Response to Endurance Training
Muscle Adaptations in Response to Resistance Training
Muscle Adaptations in Response to Decreased Physical Activity
Muscle Adaptations in Response to Injury
Sex Differences in Skeletal Muscle
Age-Associated Changes in Skeletal Muscle
Chapter 20. Muscle Strength, Power, and Flexibility
Classification of Strength Exercises
Muscle Adaptation to Progressive Resistance Exercise
Components of Muscle Strength
Delayed Onset Muscle Soreness
Progressive Resistance Training Programs
Flexibility Training
Chapter 21. Endurance Training Principles
Historical Perspective
Human Genotypes and Phenotypes
Overload, Stimulus, and Response
Three Components of a Training Session
Specificity, Skill Acquisition, and Developing Metabolism
Over-Distance Training
Interval Training
Training Variation and Peaking
Volume Versus Intensity of Training
Peripheral Versus Central Limitations
High-Altitude Training
Methods of Evaluating Training Intensity
Planning a Training Schedule
Chapter 22. Temperature Regulation and Exercise in Heat and Cold
Normal Body Temperature
Heat Transfer
Heat Production Mechanisms
Heat Loss Mechanisms
Temperature Regulation and the Hypothalamus
Exercise in the Cold
Exercise in the Heat
Thermal Stress and Heat-Related Illnesses During Exercise
Chapter 23. Atmospheric Pressure, Air Pollution, Travel, Space, and
Exercise
Altitude
Hyperbaria
Biological Rhythms and Travel Across Time Zones
Air Pollution
Space Physiology
Part IV. Exercise and Performance Factors
Chapter 24. Exercise Testing and Prescription
Medical Screening Before Beginning an Exercise Program
Understanding METs and MET-Minutes
Maximum Oxygen Consumption and Functional Capacity
Measuring Maximum Oxygen Consumption
Tests of Functional Capacity
VO2max Field Tests
Health Benefits of Physical Activity
Chapter 25. Cardiovascular Diseases
Sudden Cardiac Death and Exercise
Atherosclerosis Development
Lipoproteins
Hypertension
Heart Failure
Coronary Artery Disease Risk Factors
Cardiac Rehabilitation
Chapter 26. Obesity and Body Composition
Body Composition
Obesity and Health
Energy Balance
Obesity Treatment
Chapter 27. Disease and Disability
Chronic Diseases
Pulmonary Disorders
Immunity and Infection
Mental Health Disorders
Physical Disabilities
Bed Rest and Deconditioning
Chapter 28. Nutrition and Athletic Performance
Nutritional Practice in Athletics
Macronutrient Reports
Muscle and Dietary Carbohydrate
Amino Acid Role in Exercise
Lean Tissue Maintenance and Accretion
Fat Utilization During Exercise
Precompetition Meals
Fluid, Energy, and Electrolyte Ingestion During and After Exercise
Balanced Diet
Special Dietary Needs and Supplements
Chapter 29. Ergogenic Aids
Banned Substances
Hormonal Ergogenic Aids
Stimulants
Nutritional Ergogenic Aids and Supplements
Blood Manipulation
Gene Doping
Chapter 30. Sex and Gender Considerations
Physiological Sex Differences
Exercise and the Menstrual Cycle
The Female Athlete Triad
Exercise and Pregnancy
Chapter 31. Growth and Development
The Growth Process in Humans
Neuroendocrine Control of Growth
Exercise, Sports, and Growth
Skeletal Development During Growth
Body Composition Changes During Growth
Changes in Cardioventilatory and Metabolic Function
Developmental Responses to Training
Chapter 32. Aging
Aging Effects and Mortality
Cardiovascular Capacity
Pulmonary Function
Bone Density
Joint Health
Skeletal Muscle
Body Composition and Stature
Neural Function
Aging Theories and Exercise Effects
Exercise Prescription for Older Adults
Chapter 33. Fatigue and the Limits of Performance
Identifying Fatigue
Metabolite Depletion
Metabolite Accumulation
Oxygen Depletion and Muscle Mitochondrial Density
Central and Neuromuscular Fatigue
Psychological Fatigue
Heart Muscle Fatigue
VO2max and Endurance
Fatigue Research Technology
Chapter 1. Introduction
History of Exercise Physiology
Rate-Limiting Factors
Maximal Oxygen Consumption
Performance and Predictors of Performance
Stress and Strain
Overload Principle
Professional Field of Exercise Physiology and Exercise and Sports Science
Physical Activity and Health: Reports, Guidelines, and Recommendations
Chapter 2. Bioenergetics
Heat, Temperature, and Biological Systems
Laws of Thermodynamics
Adenosine Triphosphate
Chapter 3. ATP Homeostasis
Nonoxidative Immediate Energy System
Nonoxidative Glycolytic and Glycogenolytic Energy Systems
Oxidative Energy System
Energy Systems and Performance
Enzymatic Regulation of Metabolism
Adenylate Energy Charge
Energy Supply and Use During Physical Exercise Within the Context of Energy
Flow in the Biosphere
Chapter 4. Basics of Metabolism
Energy Transduction in the Biosphere
Metabolism and Heat Production in Animals
Early Attempts at Calorimetry
Open-Circuit Calorimeters
Respiratory Gas Exchange Ratio
Indirect Calorimetry
Chapter 5. Glycolysis and Glycogenolysis
Glycolysis
Dietary Sources of Glucose
Postprandial Lactate Shuttle
Blood Glucose Concentration During Rest and Exercise
Glycolysis in History
Glycogenolysis
Cell–Cell Lactate Shuttle
Gluconeogenesis
Effects of Training on Glycolytic Enzyme Abundances and Glycolysis
Glucose, Glycogen, and Other Substrate Use During Exercise
Effects of Exercise and Endurance Training on Blood Lactate
Chapter 6. Cellular Oxidation of Pyruvate and Lactate
Structure of the Mitochondrial Reticulum
Connectivity of the Mitochondrial Reticulum
Krebs Cycle
Electron Transport Chain
Effects of Training on Skeletal Muscle Mitochondrial Protein
Training Adaptations and Coordination of Mitochondrial and Nuclear Genes
Muscle Mitochondrial Oxygen Partial Pressure During Exercise
Free Radicals, Reactive Oxygen Species, and Oxidative Damage
Chapter 7. Lipid Metabolism
Lipid Structure
Esterification and Hydrolysis
Dietary Lipids
Free Fatty Acid Blood Levels
Intramuscular Triglycerides and Lipoproteins as Fuel Sources
Exercise Recovery and Lipid Oxidation Timing
Mitochondrial Adaptation to Enhance Fat Oxidation
Glucose–Fatty Acid (Randle) Cycle
Crossover Concept
Energy Substrate Shunting and Shuttling During Exercise
Ketones as Fuels
Chapter 8. Protein and Amino Acid Metabolism
Amino Acid and Protein Structure
Dietary Proteins
Amino Acid Pools
Gluconeogenic Amino Acids
Branched-Chain Amino Acids
Glucose-Alanine Cycle
Glutamate and Glutamine as Ammonia Scavengers
Proteomics, Metabolomics, and Fluxomics
Chapter 9. Neuroendocrine Control of Metabolism
Hormonal Control of Glycemia
Hepatic Control of Glycemia
Autonomic Nervous System and Catecholamine Control of Glycemia
Endocrine Control of Gluconeogenesis
Chapter 10. Metabolic Response to Exercise
Validity of Indirect Calorimetry in Measuring Exercise Responses
Principles of Tracer Methodology
Muscle as a Consumer of Lactate During Exercise
Excess Postexercise Oxygen Consumption (EPOC), or the O2 Debt
Historical O2 Debt Theory
Metabolic Fate of Lactate After Exercise
Exercise-Related Disturbances to Mitochondrial Function
Lactate Turnover During Exercise
Part II. Physiological Systems
Chapter 11. Pulmonary Ventilation
Breathing, Ventilation, and Respiration
Environmental Influences on Pulmonary Gas Volumes
Entry of O2 Into Blood
Pulmonary Diffusion
Red Blood Cells and Hemoglobin in CO2 Transport
Bicarbonate Buffer System
Chapter 12. Mechanics of Pulmonary Ventilation
Pulmonary Anatomy
Partial Pressures
Control of Tidal Volume and Breathing Frequency
Neural-Humoral Control of Ventilation
Chapter 13. Ventilation as a Limiting Factor
Ventilatory Perfusion Ratio (VE/Q)
Ventilatory Equivalent of Oxygen (VE/VO2) During Exercise
Maximum Expiratory Minute Ventilation Versus Maximum Voluntary Ventilation
Partial Pressures of Alveolar and Arterial Oxygen
Alveolar Surface Area for Gas Exchange
Fatigue of Ventilatory Muscles and Other Limitations
Pulmonary Limitations in Highly Trained Athletes
Chapter 14. Mechanics of the Heart
Structure of the Heart
Regulation of Cardiac Chronotropy and Inotropy
Myocardium Electrical Activity and Measurement
Cardiac Performance at Rest and During Exercise
Chapter 15. Circulation and Its Control
Mechanics of Circulation
Determinants of Blood Flow
Neural Control of the Heart
Neural Control of the Cardiovascular System
Hormonal Control Mechanisms
Metabolic Regulation of Blood Flow
Autoregulation
Cardiovascular Control During Exercise
Redistribution (Shunting) of Blood Flow During Exercise and Other Forms of
Cell Work
Chapter 16. Cardiovascular Dynamics and Exercise
Cardiovascular Responses to Exercise
Limits of Cardiovascular Performance
Changes in Cardiovascular Parameters With Training
Chapter 17. Skeletal Muscle Structure and Contractile Properties
Structure of Skeletal Muscle
Steric Block Model
Crossbridge Cycle Models
Length–Tension Relationship
Isometric Contractions
Force–Velocity Relationship
Chapter 18. Nervous System Control of Movement
Structure of the Nervous System
Excitability of Neurons
Neuromuscular Transmission
Excitation–Contraction Coupling
Muscle Fibers and Motor Unit Recruitment
Integrative Control of Movement
Motor Control Process
Part III. Adaptations to Exercise and Environment
Chapter 19. Principles of Skeletal Muscle Adaptations
Myoplasticity
Muscle Fiber Types in Elite Athletes
Muscle Adaptations in Response to Endurance Training
Muscle Adaptations in Response to Resistance Training
Muscle Adaptations in Response to Decreased Physical Activity
Muscle Adaptations in Response to Injury
Sex Differences in Skeletal Muscle
Age-Associated Changes in Skeletal Muscle
Chapter 20. Muscle Strength, Power, and Flexibility
Classification of Strength Exercises
Muscle Adaptation to Progressive Resistance Exercise
Components of Muscle Strength
Delayed Onset Muscle Soreness
Progressive Resistance Training Programs
Flexibility Training
Chapter 21. Endurance Training Principles
Historical Perspective
Human Genotypes and Phenotypes
Overload, Stimulus, and Response
Three Components of a Training Session
Specificity, Skill Acquisition, and Developing Metabolism
Over-Distance Training
Interval Training
Training Variation and Peaking
Volume Versus Intensity of Training
Peripheral Versus Central Limitations
High-Altitude Training
Methods of Evaluating Training Intensity
Planning a Training Schedule
Chapter 22. Temperature Regulation and Exercise in Heat and Cold
Normal Body Temperature
Heat Transfer
Heat Production Mechanisms
Heat Loss Mechanisms
Temperature Regulation and the Hypothalamus
Exercise in the Cold
Exercise in the Heat
Thermal Stress and Heat-Related Illnesses During Exercise
Chapter 23. Atmospheric Pressure, Air Pollution, Travel, Space, and
Exercise
Altitude
Hyperbaria
Biological Rhythms and Travel Across Time Zones
Air Pollution
Space Physiology
Part IV. Exercise and Performance Factors
Chapter 24. Exercise Testing and Prescription
Medical Screening Before Beginning an Exercise Program
Understanding METs and MET-Minutes
Maximum Oxygen Consumption and Functional Capacity
Measuring Maximum Oxygen Consumption
Tests of Functional Capacity
VO2max Field Tests
Health Benefits of Physical Activity
Chapter 25. Cardiovascular Diseases
Sudden Cardiac Death and Exercise
Atherosclerosis Development
Lipoproteins
Hypertension
Heart Failure
Coronary Artery Disease Risk Factors
Cardiac Rehabilitation
Chapter 26. Obesity and Body Composition
Body Composition
Obesity and Health
Energy Balance
Obesity Treatment
Chapter 27. Disease and Disability
Chronic Diseases
Pulmonary Disorders
Immunity and Infection
Mental Health Disorders
Physical Disabilities
Bed Rest and Deconditioning
Chapter 28. Nutrition and Athletic Performance
Nutritional Practice in Athletics
Macronutrient Reports
Muscle and Dietary Carbohydrate
Amino Acid Role in Exercise
Lean Tissue Maintenance and Accretion
Fat Utilization During Exercise
Precompetition Meals
Fluid, Energy, and Electrolyte Ingestion During and After Exercise
Balanced Diet
Special Dietary Needs and Supplements
Chapter 29. Ergogenic Aids
Banned Substances
Hormonal Ergogenic Aids
Stimulants
Nutritional Ergogenic Aids and Supplements
Blood Manipulation
Gene Doping
Chapter 30. Sex and Gender Considerations
Physiological Sex Differences
Exercise and the Menstrual Cycle
The Female Athlete Triad
Exercise and Pregnancy
Chapter 31. Growth and Development
The Growth Process in Humans
Neuroendocrine Control of Growth
Exercise, Sports, and Growth
Skeletal Development During Growth
Body Composition Changes During Growth
Changes in Cardioventilatory and Metabolic Function
Developmental Responses to Training
Chapter 32. Aging
Aging Effects and Mortality
Cardiovascular Capacity
Pulmonary Function
Bone Density
Joint Health
Skeletal Muscle
Body Composition and Stature
Neural Function
Aging Theories and Exercise Effects
Exercise Prescription for Older Adults
Chapter 33. Fatigue and the Limits of Performance
Identifying Fatigue
Metabolite Depletion
Metabolite Accumulation
Oxygen Depletion and Muscle Mitochondrial Density
Central and Neuromuscular Fatigue
Psychological Fatigue
Heart Muscle Fatigue
VO2max and Endurance
Fatigue Research Technology







