Introduces and explicates the role of the serotonin transporter - one of the key transporter proteins in behavioural pharmacology and neuropsychiatry - in the human and animal brain. The book demonstrates the relevance of the transporter and explains how this knowledge is translated into valid animal models that foster new discoveries in human neurobiology.
Introduces and explicates the role of the serotonin transporter - one of the key transporter proteins in behavioural pharmacology and neuropsychiatry - in the human and animal brain. The book demonstrates the relevance of the transporter and explains how this knowledge is translated into valid animal models that foster new discoveries in human neurobiology.
Preface: focus on serotonin transporter Allan V. Kalueff and Justin L. LaPorte; 1. Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake Beth A. Luellen, Tracy L. Gilman and Anne M. Andrews; 2. Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages Qian Li; 3. Developmental roles for the serotonin transporter Antonio M. Persico; 4. SERT models of emotional dysregulation Adam Tripp and Etienne Sibille; 5. The serotonin transporter and animal models of depression Daniela Popa, Chloé Alexandre, Joëlle Adrien and Clément Léna; 6. The serotonin transporter knockout rat: a review Jocelien Olivier, Alexander Cools, Bart Ellenbroek, Edwin Cuppen and Judith Homberg; 7. Wistar-Zagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter Lipa Cicin-Sain and Branimir Jernej; 8. The role of the serotonin transporter in reward mechanisms F. Scott Hall, Ichiro Sora, Maria T. G. Perona and George R. Uhl; 9. Modeling SERT x BDNF interactions in brain disorders: single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knockout mice Justin L. LaPorte, Renee F. Ren-Patterson, Dennis L. Murphy and Allan V. Kalueff; 10. Primate models in serotonin transporter research Khalisa N. Herman, James T. Winslow and Stephen J. Suomi; 11. The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain Klaus-Peter Lesch.
Preface: focus on serotonin transporter Allan V. Kalueff and Justin L. LaPorte; 1. Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake Beth A. Luellen, Tracy L. Gilman and Anne M. Andrews; 2. Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages Qian Li; 3. Developmental roles for the serotonin transporter Antonio M. Persico; 4. SERT models of emotional dysregulation Adam Tripp and Etienne Sibille; 5. The serotonin transporter and animal models of depression Daniela Popa, Chloé Alexandre, Joëlle Adrien and Clément Léna; 6. The serotonin transporter knockout rat: a review Jocelien Olivier, Alexander Cools, Bart Ellenbroek, Edwin Cuppen and Judith Homberg; 7. Wistar-Zagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter Lipa Cicin-Sain and Branimir Jernej; 8. The role of the serotonin transporter in reward mechanisms F. Scott Hall, Ichiro Sora, Maria T. G. Perona and George R. Uhl; 9. Modeling SERT x BDNF interactions in brain disorders: single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knockout mice Justin L. LaPorte, Renee F. Ren-Patterson, Dennis L. Murphy and Allan V. Kalueff; 10. Primate models in serotonin transporter research Khalisa N. Herman, James T. Winslow and Stephen J. Suomi; 11. The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain Klaus-Peter Lesch.
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