Extraction and Crystal Structure of Physalin B - Yang, Yan-jun
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Physalin B (C28H32O9), a main active physalin of Physalis angulata L was isolated from the whole plant of Physalis angulata L, and characterized by X-ray diffraction analysis. It crystallizes in the monoclinic system, space group P2(1) with C28H32O9, a = 12.4996(2), b = 14.35620(10), c = 14.75190(10)Å, V = 2607.97(5)Å3, Z = 4,Dc = 1.382mg/cm3, Mr = 542.56, F(000) = 1152, and mi= 0.870 mm-1. The final R = 0.0389 and wR = 0.1037 for 47670 observed reflections (I 2 (I)). The rigid molecule consists of eight fused rings involving two lactones.. There are two C28H32O9 molecules in an symmetric…mehr

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Produktbeschreibung
Physalin B (C28H32O9), a main active physalin of Physalis angulata L was isolated from the whole plant of Physalis angulata L, and characterized by X-ray diffraction analysis. It crystallizes in the monoclinic system, space group P2(1) with C28H32O9, a = 12.4996(2), b = 14.35620(10), c = 14.75190(10)Å, V = 2607.97(5)Å3, Z = 4,Dc = 1.382mg/cm3, Mr = 542.56, F(000) = 1152, and mi= 0.870 mm-1. The final R = 0.0389 and wR = 0.1037 for 47670 observed reflections (I 2 (I)). The rigid molecule consists of eight fused rings involving two lactones.. There are two C28H32O9 molecules in an symmetric unit, and the title compound is stacked into a 3D layer structure through hydrogen bonds.In the 5-20mimol/L range, physalin B can significantly inhibit the secretion of inflammatory cytokines TNF- and IL-6 on RAW264.7 cells. The results suggest that physalin B has anti-inflammatory activity in vitro.
Autorenporträt
Yan-jun Yang ¿professeur de pharmacie, impliqué dans la recherche sur les médicaments naturels actifs depuis plus de 25 ans, s'est principalement concentré sur les structures des médicaments hautement actifs et les nouveaux types de structures, a découvert 4 nouveaux composés, a obtenu 5 brevets d'invention et a publié plus de 40 articles de recherche.