Floating Drug Delivery System - Nanjwade, Basavaraj;Adichwal, Sagar A.
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Floating drug delivery system or hydrodynamically balance systems have a bulk density lower than gastric fluid and thus remains buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. While the system is floating on gastric contents the drug is released slowly at a desired rate from the system. After the release of drug residual system is emptied from the stomach. This results in increase in gastric residence time and a better control of fluctuation in plasma drug concentration. Development of oral controlled-release systems has been a challenge to…mehr

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Produktbeschreibung
Floating drug delivery system or hydrodynamically balance systems have a bulk density lower than gastric fluid and thus remains buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. While the system is floating on gastric contents the drug is released slowly at a desired rate from the system. After the release of drug residual system is emptied from the stomach. This results in increase in gastric residence time and a better control of fluctuation in plasma drug concentration. Development of oral controlled-release systems has been a challenge to formulation scientists because of their inability to restrain and localize the system in the targeted area of the gastrointestinal tract.
Autorenporträt
Prof. Dr. Basavaraj Nanjwade serves as the General Manager of Production and Operations at Search Foundation in Bengaluru, Karnataka, India. Dr. Nanjwade has developed 126 biomedical products (domestic & international markets) and has achieved 177 national and international publications. He provides guidance to M. Pharma, PhD, and Pharm D students.