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From above experimental findings it can be concluded that: ¿ Floating tablet of Clopidogrel Bisulphate can be formulated by effervescent technique using combination of different grades of HPMC. ¿ The prepared floating tablets of Clopidogrel Bisulphate showed satisfactory physicochemical properties and floating behaviour. ¿ The mechanism of drug release was found to be matrix diffusion controlled. ¿ Formulations showed satisfactory results from Stability studies. ¿ Further in-vivo investigations are necessary to correlate in-vitro data.