Sudhakar Beeravelli, Swathi Polipilli, Kolapalli Venkata Ramana Murthy

Formulation and evaluation of didanosine loaded stealth vesicles

• Broschiertes Buch

Produktbeschreibung

Vesicular systems are novel means of delivering drug in controlled manner to enhance bioavailability and get therapeutic effect over a longer period of time. Vesicles are colloidal particles in which a concentric bilayer made up of amphiphilic molecules surrounds an aqueous compartment. They are a useful means of vehicle or drug delivery of both hydrophobic drugs, which are associate with the lipid bilayer and hydrophilic drugs, which are encapsulated in the interior aqueous compartment. In general, vesicles made of natural or synthetic phospholipids are called liposomes whereas those made of nonionic surfactants (e.g.alkylethers and alkylesters) and cholesterol constitutes a nonionic surfactant vesicular system called niosomes Vesicles are commonly classified into two categories: classical and long circulating vesicles (LCV). The term classical vesicle (CV) has been used for dose-dependent pharmacokinetics and short circulation of half- lives, particularly after intravenous administration of low doses. They are rapidly cleared to the mononuclear phagocytic systems (MPS) which was problematic in the early attempts to create drug delivery systems for certain applications.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 128
• Erscheinungstermin: 15. April 2016
• Englisch
• Abmessung: 220mm x 150mm x 8mm
• Gewicht: 209g
• ISBN-13: 9783659872488
• ISBN-10: 3659872482
• Artikelnr.: 45002277

Autorenporträt

Ich bin Dr. Beeravelli Sudhakar und arbeite als wissenschaftlicher Mitarbeiter bei Therdose Pharma Pvt Ltd, Pragathi Nagar, Hyderabad, Indien. Derzeit arbeite ich an verschiedenen kolloidalen Arzneimittelsystemen wie Nanopartikeln, SLN, Liposomen und Ethosomen auf verschiedenen Anwendungswegen wie TDDS, parenteraL und oraler Verabreichung, um die Pharmakokinetik von Arzneimitteln zu verändern.