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Amongst the various route of drug administration, oral route is the most preferable one by the patients as it is easy and economical. Oral dosage forms may be conventional, sustained or controlled release. The best one is controlled release drug delivery system as it provides drug release at a predetermined, predictable and controlled rate. Earlier the patient had to take many drugs in combination and sometimes at different intervals for chronic diseases like diabetes mellitus, cancer and HIV. This treatment is prolonged, leading to patient non compliance, irritability or missing of dose resulting difficulty in treating the disease. Therefore mucoadhesive microspheres were prepared to overcome some of the problems of conventional drug delivery systems and also improve therapeutic efficacy of the drug. Mucoadhesive microspheres have a core of drug coated entirely with a mucoadhesive polymer. They have the potential to adhere to mucosa thus offering a targeted and controlled release drug delivery system.