Functional effects of flecainide and amiodarone - Mayer, Christian
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Flecainide and amiodarone are both important drugs in the treatment of arrhythmias, especially the common atrial fibrillation. Flecainide is generally the first choice for this indication because it has very good conversion rates and low relapse rates in long-term therapy. However, it is contraindicated in people with structural heart disease and severely reduced left ventricular function, which is often the case in this patient group. Amiodarone is valuable in this context as it has no negative effect on cardiac activity. Nevertheless, the direct systolic and diastolic effects of these two…mehr

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Produktbeschreibung
Flecainide and amiodarone are both important drugs in the treatment of arrhythmias, especially the common atrial fibrillation. Flecainide is generally the first choice for this indication because it has very good conversion rates and low relapse rates in long-term therapy. However, it is contraindicated in people with structural heart disease and severely reduced left ventricular function, which is often the case in this patient group. Amiodarone is valuable in this context as it has no negative effect on cardiac activity. Nevertheless, the direct systolic and diastolic effects of these two drugs are still insufficiently known, which is why they were investigated in this study on atrial human myocardium.
Autorenporträt
Christian Mayer é um médico de Graz que atua principalmente nas áreas de cardiologia e medicina de emergência. No âmbito do seu trabalho, realizou, entre outras coisas, experiências com tecido cardíaco humano e testou o efeito de diferentes fármacos neste tecido.