This book describes the essential aspects of enantioselective catalysis in a clear, logical fashion, with chapters organized by concept rather than by reaction type. Each concept in Fundamentals of Asymmetric Catalysis is supported by carefully selected examples of a wide range of catalysts, reactions and reaction mechanisms.
This book describes the essential aspects of enantioselective catalysis in a clear, logical fashion, with chapters organized by concept rather than by reaction type. Each concept in Fundamentals of Asymmetric Catalysis is supported by carefully selected examples of a wide range of catalysts, reactions and reaction mechanisms.
Patrick J. Walsh (Author) Patrick J. Walsh is a Professor of Chemistry at University of Pennsylvania. He received his B.A. from UC San Diego, where he was mentored by Prof. Charles Perrin, and his Ph.D from UC Berkeley, where he studied organometallic chemistry with Prof. Robert G. Bergman. Following an NSF postdoctoral fellowship with Prof. K. B. Sharpless at the Scripps Research Institute, he moved across town to become an assistant professor at San Diego State University and a professor at Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana (Mexico). In 1999 he moved to his current position at the University of Pennsylvania where he is currently professor of chemistry. Walsh has received several awards, most recent of which was the 2006 Philadelphia Section Award of the ACS. Walsh's interests are in asymmetric catalysis, development of new methods, reaction mechanisms, and inorganic synthesis.Marisa C. Kozlowski (Author) Marisa Kozlowski is a Professor of Chemistry at University of Pennsylvania. She received an A. B. in Chemistry from Cornell University and a Ph.D. from the University of California at Berkeley under the direction of Paul Bartlett. After studying asymmetric catalysis in the laboratories of David A. Evans at Harvard University as a National Science Foundation postdoctoral fellow, she joined the faculty at the University of Pennsylvania in 1997. Kozlowski is the recipient of a number of awards including a DuPont Young Investigator Award, an NSF Career Award, an Alfred P. Sloan Research Fellowship. The major focus of Professor Kozlowski's research is the development of methods for the design of asymmetric catalysts.
Inhaltsangabe
Foreword.- Introduction to Fundamentals of Asymmetric Catalysis.- Modes of Asymmetric Induction.- Lewis Acid and Lewis Base Catalysis .- Beyond Lewis Acid and Lewis Base Catalyzed Activation .- Asymmetric Induction in Enantioselective Catalysis .- Nonclassical Catalyst Substrate Interactions .- Chiral Poisoning, Chiral Activation, and Screening Achiral Ligands .- Kinetic Resolution .- Parallel Kinetic Resolution .- Dynamic Kinetic Resolution and Dynamic Kinetic Asymmetric Transformations .- Desymmetrization Reactions .- Nonlinear Effects, Autocatalysis, and Autoinduction .- Bifunctional, Dual, and Multifunctional Catalyst Systems .- Asymmetric Catalysis with Enantiopure Substrates: Double Diastereoselection .- Multistep Asymmetric Catalysis .- Supported Chiral Catalysts .- Applications of Asymmetric Catalysis in Synthesis .- Appendix: Terms & Enantioselective Processes in Asymmetric Catalysis .- Index.
