Fundamentals of Molecular Structural Biology, Second Edition reviews the mathematical and physical foundations of molecular structural biology, covering the latest advancements. The book begins with historical perspectives before exploring mathematical concepts, physical aspects of chemistry, the chemical basis of biology, structural analysis, visualization, protein folding, transcription, RNA processing, cell signaling, and computational molecular biology. Additionally, this new edition delves into AI fundamentals and applications, including AlphaFold and RoseTTAFold. This fully updated…mehr
Fundamentals of Molecular Structural Biology, Second Edition reviews the mathematical and physical foundations of molecular structural biology, covering the latest advancements. The book begins with historical perspectives before exploring mathematical concepts, physical aspects of chemistry, the chemical basis of biology, structural analysis, visualization, protein folding, transcription, RNA processing, cell signaling, and computational molecular biology. Additionally, this new edition delves into AI fundamentals and applications, including AlphaFold and RoseTTAFold. This fully updated edition provides a detailed overview of the fundamental concepts across molecular structural biology and acts as an ideal guide for researchers and advanced students. Given the increasingly interdisciplinary nature of this subject, this book provides early career researchers and those shifting into an adjacent field a "fundamentals" resource to get them up-to-speed on the foundations of a particular field.
Subrata Pal obtained his bachelor's and master's degrees, both in physics, from Calcutta University. Subsequently, he pursued his predoctoral research in molecular biology and received a PhD degree from the same university in 1982. He carried out his postdoctoral research in DNA replication and gene expression at two of the premiere institutions in the USA: the National Institutes of Health, Bethesda, Maryland and Harvard Medical School, Boston Massachusetts. At Harvard, he received a Claudia Adams Barr special investigator award for basic contribution to cancer research. Professor Pal has a long teaching experience at the undergraduate and graduate levels - the areas of his teaching include physics, molecular biology and genomics.
Inhaltsangabe
1. Introduction: A historical perspective 2. Mathematical preliminaries 3. Physical basis of chemistry 4. Chemical basis of biology 5. Biomacromolecules 6. Structure analysis and visualization 7. Protein Folding 8. DNA synthesis: Replication 9. Transcription 10. RNA processing 11. Translation 12. DNA damage and repair 13. Recombination 14. Membrane structure and function 15. Fundamentals of structural genomics 16. Cell signaling and systems biology 17. Macromolecular assemblies 18. Computational molecular biology 19. Artificial intelligence (AI) applications
1. Introduction - A historical perspective2. Mathematical tools3. Physical basis of chemistry4. Chemical basis of biology5. Biomacromolecules6. Structure analysis and visualization7. Protein folding8. DNA synthesis: Replication9. Transcription10. RNA processing11. Translation12. DNA damage and repair13. Recombination14. Membrane structure and function15. Fundamentals of structural genomics16. Cell signaling and systems biology17. Macromolecular assemblies18. Computational molecular biology
1. Introduction: A historical perspective 2. Mathematical preliminaries 3. Physical basis of chemistry 4. Chemical basis of biology 5. Biomacromolecules 6. Structure analysis and visualization 7. Protein Folding 8. DNA synthesis: Replication 9. Transcription 10. RNA processing 11. Translation 12. DNA damage and repair 13. Recombination 14. Membrane structure and function 15. Fundamentals of structural genomics 16. Cell signaling and systems biology 17. Macromolecular assemblies 18. Computational molecular biology 19. Artificial intelligence (AI) applications
1. Introduction - A historical perspective2. Mathematical tools3. Physical basis of chemistry4. Chemical basis of biology5. Biomacromolecules6. Structure analysis and visualization7. Protein folding8. DNA synthesis: Replication9. Transcription10. RNA processing11. Translation12. DNA damage and repair13. Recombination14. Membrane structure and function15. Fundamentals of structural genomics16. Cell signaling and systems biology17. Macromolecular assemblies18. Computational molecular biology
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