G Protein-Coupled Receptors

Structure, Function, and Ligand Screening
Herausgeber: Haga, Tatsuya; Takeda, Shigeki

• Gebundenes Buch

Produktbeschreibung

With contributions from international experts in the fields of pharmacology, neuroscience, and biochemistry, this text provides an in-depth exploration of GPCRs. Coverage includes the screening of ligands for GPCRs, physiological and molecular characterizations of GPCRs, and structures of GPCRs and their ligands. The book explores current research issues in the post-genome era, particularly the identification of endogenous ligands that may lead to finding new hormones or neurotransmitters. It also discusses the determination of the tertiary structure of GPCRs, useful for understanding GPCR interactions and for the theoretical modeling of drugs.

Produktdetails

• Verlag: CRC Press
• Seitenzahl: 336
• Erscheinungstermin: 4. August 2005
• Englisch
• Abmessung: 240mm x 161mm x 23mm
• Gewicht: 669g
• ISBN-13: 9780849327711
• ISBN-10: 0849327717
• Artikelnr.: 21746340

Autorenporträt

Tatsuya Haga, Shigeki Takeda

Inhaltsangabe

Screening of Ligands for GPCRs. Screening of Endogenous Ligands for Orphan
GPCRs. Screening of Ligands for Human GPCRs by the Use of Receptor-Ga
Fusion Proteins. Screening and Identification of Ghrelin, an Endogenous
Ligand for the Growth-Hormone-Secretagogue Receptor. Ligand Screening of
Olfactory Receptors. Functions and Regulation of GPCRs. Generation and
Phenotypical Analysis of Muscarinic Acetylcholine Receptor Knockout Mice.
Systematic Mutagenesis of M1 Muscarinic Acetylcholine Receptors. Analysis
of the Regulation of Muscarinic Acetylcholine Receptors. Single-Molecule
Analysis of Chemotactic Signaling Mediated by cAMP Receptor on Living
Cells. Oligomerization of G Protein-Coupled Purinergic Receptors. Tertiary
Structure of GPCRs and their Ligands. Methods and Results in X-ray
Crystallography of Bovine Rhodopsin. Determination of Steric Structure of
Muscarinic Ligands Bound to Muscarinic Acetylcholine Receptors: Approaches
by TRNOE (Transferred Nuclear Overhauser Effect). Modeling of G
Protein-Coupled Receptors for Drug Design.