Gamma-Delta T Cells: Unseen Immune Warriors - Shalini
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Our bodies need protection against pathogen invasion and for that we employ our immune system which is armed with an arsenal of cells and proteins. This immune network is destined to eliminate microbes and substances determined to pose significant threat to the normal functioning of our bodies by confronting viruses, bacteria, toxins, fungi and parasites, or even by battling tumoral cells. So, the immune system develops mechanisms at least equal in effectiveness and ingenuity to the infectious or transforming threat. At the same time, the maintenance of homeostasis and prevention of…mehr

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Produktbeschreibung
Our bodies need protection against pathogen invasion and for that we employ our immune system which is armed with an arsenal of cells and proteins. This immune network is destined to eliminate microbes and substances determined to pose significant threat to the normal functioning of our bodies by confronting viruses, bacteria, toxins, fungi and parasites, or even by battling tumoral cells. So, the immune system develops mechanisms at least equal in effectiveness and ingenuity to the infectious or transforming threat. At the same time, the maintenance of homeostasis and prevention of self-destruction is a very important function managed also by the immune system via tolerance mechanisms. This orchestration and customisation of the immune system aim in securing our best survival1,2. The network of immune cells is usually divided into the innate and adaptive leg (figure I.1). The first harbours ready-for-action cells (e.g. monocytes, neutrophils, natural killer cells) and the second highly specialised agents (T and B lymphocytes). Even though separated in categories the cross talks and cooperation between the two legs are constant and crucial. T and B lymphocytes recognise and bind a broad range of antigens through the highly diverse antigen receptors on their surface (T-cell receptor for T lymphocytes and B-cell receptor for B lymphocytes) and confer the essential aspect of immunological memory1. In the T spectrum, there are unconventional cases of more rapid responders such as mucosal-associated invariant T (MAIT) cells ( beta), natural killer T (NKT) cells ( beta) or the Gammad T cells3. The focus of this work is on the human Gammad T cells and especially the VGamma9Vd2 T cell population which provide unique functional specialisation.
Autorenporträt
Expertise: Environmental Epidemiology, Exposure Assessment, Low-Dose Effects Dr. Shalini is a recognized expert in environmental epidemiology, particularly the challenges associated with studying the health effects of low-level environmental exposures. Her work focuses on the critical need for accurate measurement in environmental epidemiology research. Dr. Shalini's research likely explores areas such as: The development and application of biomarkers for measuring low-dose environmental exposures Statistical methods for handling measurement error and uncertainty in dose-response relationships Designing and conducting epidemiological studies to investigate health risks from low-level exposures The challenges of causal inference in environmental health research The importance of accurate measurement for environmental risk assessment and public health policy