Gene Expression and Its Discontents - Wallace, Rodrick;Wallace, Deborah
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This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental…mehr

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Produktbeschreibung
This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer's disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.

Autorenporträt
Rodrick Wallace is a research scientist in the Division of Epidemiology at the New York State Psychiatric Institute, affiliated with Columbia University's Department of Psychiatry. He has an undergraduate degree in mathematics and a PhD in physics from Columbia, and completed postdoctoral training in the epidemiology of mental disorders at Rutgers. He worked as a public interest lobbyist, including two decades conducting empirical studies of fire service deployment, and subsequently received an Investigator Award in Health Policy Research from the Robert Wood Johnson Foundation. In addition to material on public health and public policy, he has published peer reviewed studies modeling evolutionary process and heterodox economics, as well as many quantitative analyses of institutional and machine cognition. He publishes in the military science literature, and in 2019 received one of the UK MoD RUSI Trench Gascoigne Essay Awards.