The use of gene transfer as a potential therapeutic approach represents a rapidly emerging field of basic and applied medical research that has recently begun to mature into initial clinical trials for a substantial variety of inherited as well as acquired diseases. The diseases which are being evaluated as potential targets for therapeutic approaches involving the use of genetic material encompass illnesses typically treated within a wide range of medical specialties. The field of cardiovascular medicine is no exception to this. The purpose of this book is to help those involved, considering…mehr
The use of gene transfer as a potential therapeutic approach represents a rapidly emerging field of basic and applied medical research that has recently begun to mature into initial clinical trials for a substantial variety of inherited as well as acquired diseases. The diseases which are being evaluated as potential targets for therapeutic approaches involving the use of genetic material encompass illnesses typically treated within a wide range of medical specialties. The field of cardiovascular medicine is no exception to this. The purpose of this book is to help those involved, considering involvement, or merely interested in the various aspects of gene transfer as it is being developed for the tissues of the cardiovascular system.
Preface: Molecular and Mechanical Aspects of Gene Transfer; K.L. March. Acknowledgements. Vectors and Gene Transfer Systems: Molecular Aspects of Delivery. 1. Development of Viral Vectors for Human Gene Therapy; Retrovirus and Adenovirus (Part I); B.C. Trapnell, M.N. Pensiero. 2. Adenoviruses (Part II): Improvement of Adenoviral Vectors for Human Gene Therapy: E1 and E4 Deleted Recombinant Adenoviruses; J.F. Dedieu, et al. 3. Adeno-Associated Virus and Other New DNA Virus Vectors; T.R. Floote, et al. 4. Plasmid and Other Non-Viral Vectors; L.B. Jacobsen. 5. The HVJ/Liposome Molecular Delivery System for In Vivo Genetic Engineering; G.H. Gibbons. 6. Endogenous Expression Modification: Antisense Approaches; M. Simons. Methods for Localizing Gene Transfer: Mechanical Aspects of Delivery. 7. Catheter-Based Local Drug and Gene Delivery; R.L. Wilensky. 8. Fluid Dynamics of Catheter Delivery: Effects on Delivery Efficiency and Localization; C.R. Lambert, S. Rowland. 9. Targeted and Sustained-Release Delivery Concepts in Gene Therapy; R.W. Schroff, L.L. Kunz. Gene Delivery For Local Vascular Expression. 10. Viral Vector-Based Vascular Gene Delivery: Basic Studies and Therapeutic Applications; E.G. Nabel. 11. Cell-Based Vascular Gene Delivery: Endothelial Cells as Carriers; J. Burke, et al. 12. Cell-Based Gene Delivery: Smooth Muscle Cells as Carriers; A.W. Clowes. 13. Vascular Cell Proliferation Dynamics: Implications for Gene Transfer and Restenosis; R.S. Schwartz, et al. 14. Angiogenesis and Collateral Formation; J.M. Isner. Gene Delivery for Local Cardiac Expression. 15. Cell-Based Myocardial Protein Delivery; M.H. Soonpaa, L.J. Field. 16. Skeletal Myoblast Therapy in Cardiovascular Disease; D.A. Taylor, et al. 17. Adenovirus and the Myocardium; J.A. Towbin. Gene Delivery for Systemic Expression. 18. Gene Delivery for Systemic Expression: Plasmid, Retroviral, and Adenoviral Approaches; K. Parker Ponder. 19. Adenoviral Gene Delivery Approaches for Systemic Expression; S.C. Stevenson, A. McClelland. 20. Experimental Approaches Using Kallikrein Gene Therapy for Hypertension; J. Chao, L. Chao. Biophysical Considerations in Vector Delivery. 21. Pharmacokinetics of Local Vector Delivery to Vascular Tissues: Implications for Efficiency and Localization; K.L. March, B. Trapnell. Color Plates. Index.
Preface: Molecular and Mechanical Aspects of Gene Transfer; K.L. March. Acknowledgements. Vectors and Gene Transfer Systems: Molecular Aspects of Delivery. 1. Development of Viral Vectors for Human Gene Therapy; Retrovirus and Adenovirus (Part I); B.C. Trapnell, M.N. Pensiero. 2. Adenoviruses (Part II): Improvement of Adenoviral Vectors for Human Gene Therapy: E1 and E4 Deleted Recombinant Adenoviruses; J.F. Dedieu, et al. 3. Adeno-Associated Virus and Other New DNA Virus Vectors; T.R. Floote, et al. 4. Plasmid and Other Non-Viral Vectors; L.B. Jacobsen. 5. The HVJ/Liposome Molecular Delivery System for In Vivo Genetic Engineering; G.H. Gibbons. 6. Endogenous Expression Modification: Antisense Approaches; M. Simons. Methods for Localizing Gene Transfer: Mechanical Aspects of Delivery. 7. Catheter-Based Local Drug and Gene Delivery; R.L. Wilensky. 8. Fluid Dynamics of Catheter Delivery: Effects on Delivery Efficiency and Localization; C.R. Lambert, S. Rowland. 9. Targeted and Sustained-Release Delivery Concepts in Gene Therapy; R.W. Schroff, L.L. Kunz. Gene Delivery For Local Vascular Expression. 10. Viral Vector-Based Vascular Gene Delivery: Basic Studies and Therapeutic Applications; E.G. Nabel. 11. Cell-Based Vascular Gene Delivery: Endothelial Cells as Carriers; J. Burke, et al. 12. Cell-Based Gene Delivery: Smooth Muscle Cells as Carriers; A.W. Clowes. 13. Vascular Cell Proliferation Dynamics: Implications for Gene Transfer and Restenosis; R.S. Schwartz, et al. 14. Angiogenesis and Collateral Formation; J.M. Isner. Gene Delivery for Local Cardiac Expression. 15. Cell-Based Myocardial Protein Delivery; M.H. Soonpaa, L.J. Field. 16. Skeletal Myoblast Therapy in Cardiovascular Disease; D.A. Taylor, et al. 17. Adenovirus and the Myocardium; J.A. Towbin. Gene Delivery for Systemic Expression. 18. Gene Delivery for Systemic Expression: Plasmid, Retroviral, and Adenoviral Approaches; K. Parker Ponder. 19. Adenoviral Gene Delivery Approaches for Systemic Expression; S.C. Stevenson, A. McClelland. 20. Experimental Approaches Using Kallikrein Gene Therapy for Hypertension; J. Chao, L. Chao. Biophysical Considerations in Vector Delivery. 21. Pharmacokinetics of Local Vector Delivery to Vascular Tissues: Implications for Efficiency and Localization; K.L. March, B. Trapnell. Color Plates. Index.
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