Presenting all preclinical and clinical information available on genetically engineered toxins, this unique, single-source reference provides the most up-to-date methods and practical examples for conducting clinical studies in toxin molecular biology.;Reviewing difficult problems and their solutions, Genetically Engineered Toxins discusses techniq
Presenting all preclinical and clinical information available on genetically engineered toxins, this unique, single-source reference provides the most up-to-date methods and practical examples for conducting clinical studies in toxin molecular biology.;Reviewing difficult problems and their solutions, Genetically Engineered Toxins discusses techniq
Strategies and techniques - general methods Robert F. Weaver cloning strategies Richard Intres and John W. Crabb protein engineering strategies Marc Whitlow general strategies in in vivo animal modelling Daniel A. Vallera and Bruce R. Blazar; ricin - molecular cloning of ricin Lynne R. Roberts et al expression of plant-derived ribosome-inactivating proteins in heterologous systems Michael Piatak Jr and Noriyuki Habuka the structure of plant toxins as a guide to rational design Jon D. Robertus chemical and genetic characterization of the enzymatic activity associated with ricin A chain Lawrence Greenfield chimeric proteins containing ricin A chain J. Michael Lord et al; plant hemitoxins - studies on ribosome-inactivating proteins from Saponaria officinalis Marco R. Soria et al cloning and expression of trichosanthin and - momorcharin cDNA Pang-Chui shaw et al cloning and expression of a Luffa ribosome-inactivating-related protein Bi-Yu Li and S. Ramakrishnan; fungal ribotoxins - the Aspergillus ribonucleolytic toxins (ribotoxins) Bernard Lamy et al an efficient expression system for -sarcin in Escherichia coli Yaeta Endo et al; diphtheria toxin - diphtheria toxin cloning and expression in corynebacterium diphtheriae Lawrence Greenfield diphtheria toxin expression in Escherichia coli Lawrence Greenfield the structure of diphtheria toxin as a guide to rational design Peter J. Nicholls and Richard J. Youle protein engineering of diphtheria toxin - development of receptor-specific cytotoxic agents for the treatment of human disease John R. Murphy et all in vivo studies with chimeric toxins - interleukin-2 fusion toxins as immunosuppressive agents Michael E. Shapiro et al initial clinical experiences with an interleukin-2 fusion toxin (DAB 486-IL-2) Carole M. Meneghetti and C.F. Le Maistre; pseudomonas exotoxins - pseudomonas aeruginosa exotoxin A G. Jiliani Chaudry et al expression of growth factor - toxin fusion proteins Gwynneth M. Edwards et al the structure of pseudomonas exotoxin A as a guide to rational design Peter J. Nichols and Richard J. Youle generation of chimeric toxins David FitzGerald et al; conclusions - genetically engineered toxins in perspective Sjur Olsnes and Arthur E. Frankel Appendix - primary amino acid sequences of toxins Paul Sehnke and Alexander Tonevistsky.
Strategies and techniques - general methods Robert F. Weaver cloning strategies Richard Intres and John W. Crabb protein engineering strategies Marc Whitlow general strategies in in vivo animal modelling Daniel A. Vallera and Bruce R. Blazar; ricin - molecular cloning of ricin Lynne R. Roberts et al expression of plant-derived ribosome-inactivating proteins in heterologous systems Michael Piatak Jr and Noriyuki Habuka the structure of plant toxins as a guide to rational design Jon D. Robertus chemical and genetic characterization of the enzymatic activity associated with ricin A chain Lawrence Greenfield chimeric proteins containing ricin A chain J. Michael Lord et al; plant hemitoxins - studies on ribosome-inactivating proteins from Saponaria officinalis Marco R. Soria et al cloning and expression of trichosanthin and - momorcharin cDNA Pang-Chui shaw et al cloning and expression of a Luffa ribosome-inactivating-related protein Bi-Yu Li and S. Ramakrishnan; fungal ribotoxins - the Aspergillus ribonucleolytic toxins (ribotoxins) Bernard Lamy et al an efficient expression system for -sarcin in Escherichia coli Yaeta Endo et al; diphtheria toxin - diphtheria toxin cloning and expression in corynebacterium diphtheriae Lawrence Greenfield diphtheria toxin expression in Escherichia coli Lawrence Greenfield the structure of diphtheria toxin as a guide to rational design Peter J. Nicholls and Richard J. Youle protein engineering of diphtheria toxin - development of receptor-specific cytotoxic agents for the treatment of human disease John R. Murphy et all in vivo studies with chimeric toxins - interleukin-2 fusion toxins as immunosuppressive agents Michael E. Shapiro et al initial clinical experiences with an interleukin-2 fusion toxin (DAB 486-IL-2) Carole M. Meneghetti and C.F. Le Maistre; pseudomonas exotoxins - pseudomonas aeruginosa exotoxin A G. Jiliani Chaudry et al expression of growth factor - toxin fusion proteins Gwynneth M. Edwards et al the structure of pseudomonas exotoxin A as a guide to rational design Peter J. Nichols and Richard J. Youle generation of chimeric toxins David FitzGerald et al; conclusions - genetically engineered toxins in perspective Sjur Olsnes and Arthur E. Frankel Appendix - primary amino acid sequences of toxins Paul Sehnke and Alexander Tonevistsky.
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