Volume 3 of the Guide to the Guidelines series takes readers through clinical vignettes, pancreaticobiliary and liver disease diagnosis and treatment according to the recommendations of the American College of Gastroenterology's clinical guidelines. In Chapter 1, Don't Mess with the Pancreas, the authors summarize all the guidelines on acute pancreatitis, chronic pancreatitis, and pancreatic cysts. In Chapter 2, Bile and Brimstone, reviews the guidelines on various biliary disorders, including primary sclerosing cholangitis (PSC) and management of bile duct strictures. Finally, in Chapter 3, Liver Me Timbers!, the authors cover the many and splendorous ACG guidelines on liver diseases, including liver test interpretation, drug-induced liver injury, acute liver failure, acute-on-chronic liver failure, focal liver lesions, hereditary hemochromatosis, hepatic and mesenteric circulation, liver disease and pregnancy, and alcohol-related liver disease.