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Digital healthcare is rapidly evolving through AI, mobile health, electronic health, telemedicine, and wearable technologies, transforming patient care, workflow efficiency, and personalized medicine. This reprint of the Special Issue presents research and reviews on virtual interventions, mobile apps, chatbots, and wearable devices, highlighting innovations, challenges, and future directions in modern healthcare delivery. It explores patient-centered approaches, remote monitoring, and the potential of emerging technologies to improve accessibility, outcomes, and clinical decision-making.