Heparinase and low molecular weight heparins as antitumor agents - Nsayef Muslim, Sahira;Abd Ali AL-Kadmy, Israa M.S.;Al-Khfajy, Alaa N. Mohammed Ali
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Heparan sulfate and chondroitin sulfate, play a key role in the extracellular matrix. Heparin is an acidic polysaccharide, characterized by a disaccharide repeating unit of hexosamine and uronic acid (L-iduronic or D-glucuronic acid) connected through 1-4 linkages.Heparin is heterogeneous due to the varying degree of modification of the functional groups in the disaccharide unit. Heparin may be hydrolyzed with acid only under vigorous condition which results in considerable caramelization, especially of the glucoronic acid and extensive splitting of heparin.Thus, the product are mono(or) disaccharides from which all the sulphated groups are removed.…mehr

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Produktbeschreibung
Heparan sulfate and chondroitin sulfate, play a key role in the extracellular matrix. Heparin is an acidic polysaccharide, characterized by a disaccharide repeating unit of hexosamine and uronic acid (L-iduronic or D-glucuronic acid) connected through 1-4 linkages.Heparin is heterogeneous due to the varying degree of modification of the functional groups in the disaccharide unit. Heparin may be hydrolyzed with acid only under vigorous condition which results in considerable caramelization, especially of the glucoronic acid and extensive splitting of heparin.Thus, the product are mono(or) disaccharides from which all the sulphated groups are removed.
Autorenporträt
Dr. Sahira Nsayef Muslim promovierte in Mikrobiologie-Biotechnologie mit dem Titel: "Biochemische und genetische Studien über das von Aeromonas hydrophila produzierte Hämolysin, isoliert von Durchfallpatienten und aus Oberflächenwasser" Coll. Wissenschaftliche Fakultät der Mustansiryia Universität - 2005.