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Combinatorial chemistry in conjunction with High Throughput Screening(HTS) is revolutionizing the drug discovery process. Yet, we have muchto learn about the integration of these powerful techniques withinformation from genomics, proteomics, computation and pharmacokineticsbefore dramatic increases in the drug discovery/development processescan be achieved. The chapters in this book represent the state of theart regarding the integration of combinatorial chemistry and HTS inconnection with anti-inflammatory targets. Obviously, there is much workto be done beyond what is described in this text, nevertheless, itshould set the stage for creative thinking among scientists of manydisciplines for the accomplishment of our ultimate goals in treatinginflammatory diseases.