Human Epigenetics: How Science Works - Carlberg, Carsten;Molnár, Ferdinand
57,99 €
inkl. MwSt.
Versandkostenfrei*
Versandfertig in 6-10 Tagen
payback
29 °P sammeln
  • Broschiertes Buch

The view "It's all in our genes and we cannot change it" developed in the past 150 years since Gregor Mendel's experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes…mehr

Andere Kunden interessierten sich auch für
Produktbeschreibung
The view "It's all in our genes and we cannot change it" developed in the past 150 years since Gregor Mendel's experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer.

This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described.

The book represents an updated but simplified version of our textbook "Human Epigenomics" (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.

Autorenporträt
Carsten Carlberg graduated in 1989 with a Ph.D. in biochemistry at the Free University Berlin (Germany). After positions as Postdoc at Roche (Basel, Switzerland), Group Leader at the University of Geneva (Switzerland) and Docent at the University of Düsseldorf (Germany), he is since 2000 Full Professor of biochemistry at the University of Eastern Finland in Kuopio (Finland). Since 2022, Prof. Carlberg is ERA Chair for nutrigenomics at the Polish Academy of Science. His work focuses on mechanisms of gene regulation by nuclear hormones, in particular on vitamin D. At present, Prof. Carlberg's projects focus on epigenome-wide effects of vitamin D on the human immune system in the context of cancer. Stine Marie Ulven graduated in 2000 with a Ph.D. in nutrition at the University of Oslo (Norway). Since 2015 she is professor at the Department of Nutrition, Institute of Basic Medical Sciences at the University of Oslo (Norway). The main research interests of Prof. Ulven are human dietary intervention studies and diet-gene interactions with particular focus on the role of dietary fat in prevention of chronic diseases. Eunike Velleuer graduated in 2006 as M.D. at the University of Düsseldorf (Germany) and specialized in 2016 in pediatric hemato-oncology. At present, she serves as Senior Physician at the Helios Children's Clinic Krefeld as well as Research Associate at the University of Düsseldorf. Her special clinical focus is the cancer predisposition syndrome Fanconi anemia. Herein, her research interest is early detection and prevention of oral squamous cell carcinoma. Furthermore, Dr. Velleuer is interested in increasing patients' resilience and finding alternative ways for long-lasting empowerment.