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Hybrid prosthesis has emerged as a pivotal modality in contemporary prosthodontics, offering a unique blend of functional stability, biomechanical efficiency, and esthetic rehabilitation. It serves as a vital treatment option for edentulous and partially edentulous patients, particularly in situations of severe ridge resorption and implant-supported restorations where conventional fixed or removable prostheses have limitations.This book critically reviews the principles, design concepts, and clinical applications of hybrid prosthesis, integrating classical foundations with modern scientific evidence. Emphasis is placed on the balance between biomechanics, material science, and clinical execution to achieve predictable long-term outcomes. Advances in digital dentistry, including CAD/CAM technology and virtual planning, are highlighted as transformative tools that have enhanced precision and treatment predictability.By synthesizing evidence-based literature and contemporary innovations, this work provides a comprehensive perspective on hybrid prosthesis as a reliable and versatile option in complex prosthodontic rehabilitation.