Imaging in Photodynamic Therapy

Herausgeber: Hamblin, Michael R.; Huang, Yingying

• Gebundenes Buch

Produktbeschreibung

This book covers the broad field of cellular, molecular, preclinical and clinical imaging associated or combined with photodynamic therapy (PDT). It reflects how the large strides made by PDT in clinical use have resulted in increased studies with imaging elements to optimize treatment. The first sections address basic background, followed by cellular imaging approaches for localization of different photosensitizers and the study of cell damage. The next chapters then discuss theranostic agents, small animal imaging, and clinical imaging.

Produktdetails

• Verlag: CRC Press
• Seitenzahl: 502
• Erscheinungstermin: 1. Februar 2017
• Englisch
• Abmessung: 260mm x 183mm x 31mm
• Gewicht: 1130g
• ISBN-13: 9781498741453
• ISBN-10: 1498741452
• Artikelnr.: 54588047

Autorenporträt

Michael R Hamblin Ph.D. is a Principal Investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital, an Associate Professor of Dermatology at Harvard Medical School and is a member of the affiliated faculty of the Harvard-MIT Division of Health Science and Technology. His research interests lie in the areas of photodynamic therapy (PDT) for infections, cancer, and stimulation of the immune system, and in low-level light therapy (LLLT) for wound healing, arthritis, traumatic brain injury, neurodegenerative diseases and psychiatric disorders. He directs a laboratory of around a dozen post-doctoral fellows, visiting scientists and graduate students. His research program is supported by NIH, CDMRP, USAFOSR and CIMIT among other funding agencies. He has published 272 peer-reviewed articles, over 150 conference proceedings, book chapters and International abstracts and holds 8 patents. He is Associate Editor for 7 journals, on the editorial board of a further 12 journals and serves on NIH Study Sections. For the past 10 years Dr Hamblin has chaired an annual conference at SPIE Photonics West entitled "Mechanisms for low level light therapy" and he has edited the 10 proceedings volumes together with four other major textbooks on PDT and photomedicine. He has several other book projects in progress at various stages of completion. In 2011 Dr Hamblin was honored by election as a Fellow of SPIE. Ying-Ying Huang, M.D., is a scientist in Dr. Michael Hamblin's lab in Wellman Center for Photomedicine at Massachusetts General Hospital, an Instructor of Dermatology at Harvard Medical School. She was trained as a dermatologist in China. She has been at MGH Wellman Center for 5 years. Her research interests lie in the areas of photodynamic therapy (PDT) for infections, cancer and mechanism of low level light therapy (LLLT) for traumatic brain injury. She has published 48 peer review articles and 15 conference proceedings and book chapters. She is the co-editor of newly released Handbook of Photomedicine

Inhaltsangabe

INTRODUCTION. Looking out the optical window: Physical principles and
instrumentation of imaging in photodynamic therapy. Photochemistry and
photophysics of PDT and photosensitizers. IN VITRO MICROSCOPY FOR
PHOTOSENSITIZER LOCALIZATION IN CELLS. Phthalocyanines in photodynamic
therapy. Singlet oxygen luminescence imaging: A prospective tool in
bioscience? Microbial biofilms and antimicrobial photodynamic therapy.
High-content imaging for photosensitizer screening. IN VITRO MICROSCOPY OF
CELL DAMAGE AND DEATH PROCESSES AFTER PDT. Enhanced efficacy of
photodynamic therapy via an iron-lysosome-mitochondria connection: Studies
with phthalocyanine 4. Role of cell death pathways in response to
photodynamic therapy in gliomas. In search of specific PDT
photosensitizers: Subcellular localization and cell death pathways.
THERANOSTIC AGENTS AND NANOTECHNOLOGY. Quantum dots in PDT.
Tetrapyrrole-based theranostic combinations of photodynamic action and
magnetic resonance imaging. Theranostic applications of photodynamic
molecular beacons. Tumor-specific imaging and photodynamic therapy
targeting the urokinase receptor. SMALL ANIMAL IMAGING. Vascular imaging in
photodynamic therapy. Photosensitizer activity imaging on the microscopic
scale. Bioluminescence imaging for monitoring the effectiveness of
photodynamic therapy for infections in animal models. CLINICAL IMAGING.
Imaging of photosensitizers in skin. Brain tumor imaging with ALA. PDT of
non-muscle-invasive bladder cancer with Hexylester Aminolevulinate:
Optimization of the illumination wavelengths by fluorescence spectroscopy
and imaging. Endoscopic imaging and photodynamic therapy. Spectroscopic
imaging in prostate PDT. Fluorescent-guided resection in clinical oncology.