Implantable sensor systems offer great potential for enhanced medical care and improved quality of life, consequently leading to major investment in this exciting field. Implantable sensor systems for medical applications provides a wide-ranging overview of the core technologies, key challenges and main issues related to the development and use of these devices in a diverse range of medical applications.Part one reviews the fundamentals of implantable systems, including materials and material-tissue interfaces, packaging and coatings, microassembly, electrode array design and fabrication, and…mehr
Implantable sensor systems offer great potential for enhanced medical care and improved quality of life, consequently leading to major investment in this exciting field. Implantable sensor systems for medical applications provides a wide-ranging overview of the core technologies, key challenges and main issues related to the development and use of these devices in a diverse range of medical applications.Part one reviews the fundamentals of implantable systems, including materials and material-tissue interfaces, packaging and coatings, microassembly, electrode array design and fabrication, and the use of biofuel cells as sustainable power sources. Part two goes on to consider the challenges associated with implantable systems. Biocompatibility, sterilization considerations and the development of active implantable medical devices in a regulated environment are discussed, along with issues regarding data protection and patient privacy in medical sensor networks. Applications of implantable systems are then discussed in part three, beginning with Microelectromechanical systems (MEMS) for in-vivo applications before further exploration of tripolar interfaces for neural recording, sensors for motor neuroprostheses, implantable wireless body area networks and retina implants.With its distinguished editors and international team of expert contributors, Implantable sensor systems for medical applications is a comprehensive guide for all those involved in the design, development and application of these life-changing technologies.
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Autorenporträt
Dr. Andreas Inmann is a consultant and entrepreneur specializing in the development and commercialization of medical devices.
Dr. Diana Hodgins is Managing Director of European Technology for Business, Ltd., a UK-based company that specializes in the design of microsystems and sensors.
Inhaltsangabe
Contributor contact details
Woodhead Publishing Series in Biomaterials
Foreword
Introduction
Part I: Fundamentals of implantable systems
Chapter 1: Materials for implantable systems
Abstract:
1.1 Introduction
1.2 Interactions between materials and the biological medium
1.3 Electrodes
1.4 Preferred electrode metals, compounds and polymers
1.5 Leads and interconnects
1.6 Packaging
1.7 Surface preparation
1.8 Conclusions
1.9 Future trends
1.10 Sources of further information
1.11 Acknowledgements
Chapter 2: Materialâ?"tissue interfaces in implantable systems
Abstract:
2.1 Introduction
2.2 Fundamental requirements of material-tissue interfaces
2.3 Material selection for implantable systems
2.4 Design considerations and packaging concepts
2.5 Approaches to reduce reactions at the material-tissue interface
2.6 Conclusions
2.7 Future trends
2.8 Sources of further information
Chapter 3: Packaging and coating materials for implantable devices
Abstract:
3.1 Introduction
3.1.1 Background
76 Implantable sensor systems for medical applications 3.1.3 Current packaging and coating strategies
3.2 Packaging of the passive device surface
80 Implantable sensor systems for medical applications 3.2.2 Silicone
3.3 Coating of active device surfaces
3.4 Coatings and barriers for drug release
3.5 Enhancement of surface biocompatibility
3.6 Conclusions
3.7 Future trends
Chapter 4: Microassembly and micropackaging of implantable systems
Abstract:
4.1 Introduction
4.2 Components of an implanted sensor system
4.3 Microassembly
4.4 Micropackaging
4.5 Conclusions
4.6 Future trends
4.7 Sources of further information
Chapter 5: Electrode array design and fabrication for implantable systems
Abstract:
5.1 Introduction
5.2 General requirements for implantable electrode arrays
5.3 Materials for implantable electrodes
5.4 The processing of silicone as a substrate material
5.5 Coating layers for microelectrodes
5.6 Fabrication of electrodes using platinum
5.7 Microelectrode arrays - design and fabrication
5.8 Advantages and disadvantages of existing fabrication processes
5.9 Risks
5.10 Conclusions
5.11 Future trends
5.12 Sources of further information
Chapter 6: Biofuel cells as sustainable power sources for implantable systems
Abstract:
6.1 Introduction
6.2 Implantable biofuel cells
6.3 Design considerations
6.4 State-of-the-art and practical examples
6.5 Conclusions and future trends
6.6 Sources of further information
Part II: Challenges of implantable systems
Chapter 7: Biocompatibility of implantable systems
Abstract:
7.1 Introduction
7.2 The nature of the biological milieu
7.3 The course of events following insertion of an implantable system
7.4 Interfacial interactions
7.5 Biological and chemical processes which can affect implantable systems
7.6 Modelling protein adsorption
7.7 The immune response
7.8 Hydrodynamic aspects of biocompatibility
7.9 Tribological aspects of biocompatibility
7.10 Corrosion
7.11 Cell-implant interactions
7.12 The metrology and evaluation of biocompatibility
7.13 Conclusions
7.14 Future trends
7.15 Sources of further information
Chapter 8: Sterilisation considerations for implantable sensor systems
1.2 Interactions between materials and the biological medium
1.3 Electrodes
1.4 Preferred electrode metals, compounds and polymers
1.5 Leads and interconnects
1.6 Packaging
1.7 Surface preparation
1.8 Conclusions
1.9 Future trends
1.10 Sources of further information
1.11 Acknowledgements
Chapter 2: Materialâ?"tissue interfaces in implantable systems
Abstract:
2.1 Introduction
2.2 Fundamental requirements of material-tissue interfaces
2.3 Material selection for implantable systems
2.4 Design considerations and packaging concepts
2.5 Approaches to reduce reactions at the material-tissue interface
2.6 Conclusions
2.7 Future trends
2.8 Sources of further information
Chapter 3: Packaging and coating materials for implantable devices
Abstract:
3.1 Introduction
3.1.1 Background
76 Implantable sensor systems for medical applications 3.1.3 Current packaging and coating strategies
3.2 Packaging of the passive device surface
80 Implantable sensor systems for medical applications 3.2.2 Silicone
3.3 Coating of active device surfaces
3.4 Coatings and barriers for drug release
3.5 Enhancement of surface biocompatibility
3.6 Conclusions
3.7 Future trends
Chapter 4: Microassembly and micropackaging of implantable systems
Abstract:
4.1 Introduction
4.2 Components of an implanted sensor system
4.3 Microassembly
4.4 Micropackaging
4.5 Conclusions
4.6 Future trends
4.7 Sources of further information
Chapter 5: Electrode array design and fabrication for implantable systems
Abstract:
5.1 Introduction
5.2 General requirements for implantable electrode arrays
5.3 Materials for implantable electrodes
5.4 The processing of silicone as a substrate material
5.5 Coating layers for microelectrodes
5.6 Fabrication of electrodes using platinum
5.7 Microelectrode arrays - design and fabrication
5.8 Advantages and disadvantages of existing fabrication processes
5.9 Risks
5.10 Conclusions
5.11 Future trends
5.12 Sources of further information
Chapter 6: Biofuel cells as sustainable power sources for implantable systems
Abstract:
6.1 Introduction
6.2 Implantable biofuel cells
6.3 Design considerations
6.4 State-of-the-art and practical examples
6.5 Conclusions and future trends
6.6 Sources of further information
Part II: Challenges of implantable systems
Chapter 7: Biocompatibility of implantable systems
Abstract:
7.1 Introduction
7.2 The nature of the biological milieu
7.3 The course of events following insertion of an implantable system
7.4 Interfacial interactions
7.5 Biological and chemical processes which can affect implantable systems
7.6 Modelling protein adsorption
7.7 The immune response
7.8 Hydrodynamic aspects of biocompatibility
7.9 Tribological aspects of biocompatibility
7.10 Corrosion
7.11 Cell-implant interactions
7.12 The metrology and evaluation of biocompatibility
7.13 Conclusions
7.14 Future trends
7.15 Sources of further information
Chapter 8: Sterilisation considerations for implantable sensor systems
Abstract:
8.1 Introduction
8.2 Global markets and the regulatory context
8.3 Methods for sterilisation of medical devices
8.4 Sterilisation of implantable sensor systems
8.5 Conclusio
Rezensionen
"The book really illustrates the complexity when it comes to biosensor development and implantation, which will encourage a lot of researchers to broaden their perspective beyond their own research area." --Drs. Elke Van De Walle, Ghent University, Belgium. Biomaterials Network
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