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L'infection chronique par le virus de l'hépatite B (VHB) est un processus dynamique reflétant les interactions entre le VHB et la réponse immunitaire de l'hôte. Les patients infectés par le VHB ne développent pas obligatoirement une hépatite chronique B. L'infection chronique à antigène HBe négatif appelée selon l'ancienne nomenclature portage chronique inactif, constitue l'une des cinq phases de l'histoire naturelle de l'hépatite B. Les "porteurs inactifs" sont des patients ayant une maladie quiescente et ne développent généralement pas de complications. Certains facteurs sont prédictifs de perte de l'antigène HBs au cours de leur suivi. Cependant, la réactivation virale (RV) spontanée ou sous immunosuppresseurs est possible.