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This monograph provides a comprehensive analysis of the pathogenesis, clinical course, and pharmacotherapeutic approaches to ischemic heart disease (IHD). IHD, a condition resulting from inadequate blood supply to the heart muscle or complete cessation of blood flow, can lead to conditions such as myocardial infarction, angina, and other cardiovascular disorders. The monograph delves into the molecular and cellular mechanisms involved in the development of IHD, primarily focusing on atherosclerosis and the narrowing of blood vessels. It describes key clinical features, symptoms, diagnostic methods, and the latest treatment strategies. Additionally, the effectiveness of pharmacotherapy approaches, including the role of angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, statins, and thrombolytic agents, is explored in detail.