Leishmaniasis and the role of Iron - Zaidi, Amir
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The unicellular kinetoplastid protozoan parasites of genus Leishmania are the causative agents of complex neglected diseases called leishmaniasis and continue to be a significant health concern globally. Chapter 1 provide a brief overview of leishmaniasis and outline the number of drugs available for the treatment along with the possible targeted pathway in Leishmania parasite. The aim of chapter 2 is to provide an update on the current knowledge about iron acquisition and usage by Leishmania species. For the parasite survival and virulence, iron as metal ion plays a crucial role in many…mehr

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Produktbeschreibung
The unicellular kinetoplastid protozoan parasites of genus Leishmania are the causative agents of complex neglected diseases called leishmaniasis and continue to be a significant health concern globally. Chapter 1 provide a brief overview of leishmaniasis and outline the number of drugs available for the treatment along with the possible targeted pathway in Leishmania parasite. The aim of chapter 2 is to provide an update on the current knowledge about iron acquisition and usage by Leishmania species. For the parasite survival and virulence, iron as metal ion plays a crucial role in many facets of cellular metabolism as a cofactor of several enzymes. Iron acquisition is essential for the survival of parasites. Since iron plays central roles in the host's response and parasite metabolism, a comprehensive understanding of the iron metabolism is beneficial to identify potential viable therapeutic opportunities against leishmaniasis.
Autorenporträt
Amir Zaidi, M.Sc. Biochemie von Jamia Hamdard, Neu-Delhi und Ph.D. (Biochemie) von der Universität von Kalkutta. Er untersuchte die Fe-S-Cluster-Maschinerie des Modellpathogens Leishmania donovani, das viszerale Leishmaniose verursacht.