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Ankle sprains are common injuries, particularly in sports and physical activities, and though they may seem minor at first, they can cause significant pain and disrupt daily routines. The standard treatment for such sprains often involves external therapies, with topical applications such as Lepa being central to the healing process. This research focuses on the effectiveness of two Ayurvedic formulations - Kolakulatthadi Lepa and Manjisthadi Lepa - in treating Rujakarmarmakshat, a term from Ayurveda referring to injuries of the ankle joint (Gulpha Sandhi). These formulations are discussed within the broader context of Ayurvedic principles of disease prevention and management.