This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.
This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.
Haruhisa Inoue, CiRA, Kyoto University, Japan; RIKEN BRC, Japan; RIKEN AIP, JAPAN Yukio Nakamura, RIKEN BioResource Center, Japan
Inhaltsangabe
Introduction. Overview.- Disease Modeling. iPSCs for disease modeling.- Reprogramming cancer cells.- Recapitulating hematopoiesis in the lab.- Modeling cardiomyopathies with iPSCs.- Molecular Technologies. Controling cell state with intracellular biomarkers.- Genome editing of stem cells.- iPS Applications. iPSC-based cell therapy for eye diseases.- 3D models for organ development.- Drug discovery using iPSCs.- Direct differentiation of neural cells.
Introduction. Overview.- Disease Modeling. iPSCs for disease modeling.- Reprogramming cancer cells.- Recapitulating hematopoiesis in the lab.- Modeling cardiomyopathies with iPSCs.- Molecular Technologies. Controling cell state with intracellular biomarkers.- Genome editing of stem cells.- iPS Applications. iPSC-based cell therapy for eye diseases.- 3D models for organ development.- Drug discovery using iPSCs.- Direct differentiation of neural cells.
Rezensionen
"The book is most appropriate for those with a basic understanding of molecular biology and stem cell function, with value for students, researchers, and instructors interested in the area of iPS cell biology. ... it serves as an excellent resource for those studying this topic and provides a chronological perspective, appropriately discussing many of the key applications and challenges." (Thomas Bodenstine, Doody's Book Reviews, June 21, 2019)
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