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Mesenchymal hamartoma of the liver is a rare, benign tumor. Its clinical symptoms are non-specific. Diagnosis is based on a number of factors. However, confirmation remains histological. A review of 5 cases from the Fattouma Bourguiba pediatric surgery department in Monastir over a 16-year period revealed the clinical, radiological and anatomopathological features of this tumor. Five children aged 1 day, 5 months, 12 months and 16 months respectively, with a sex ratio = 4/1, presented with abdominal distension. An antenatal finding was noted in 1 patient. AlphaFP was elevated in 3 patients. Localization in the right lobe was predominant. All our patients underwent surgical treatment: two infants had a right hepatectomy and 3 others had an incomplete cyst resection. Our patients are in good general condition, with an average follow-up of 4 years. No recurrence or malignant transformation was noted.