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Among the drugs that are administered orally, solid oral dosage forms represents the preferred choice of class of product. Commonly used solid oral dosage forms are tablets and capsules; tablets are indeed the most popular solid dosage form for oral administration. Controlled release capsules, often containing a plurality of coated pellets, is yet another category of solid oral formulation that offers analogous therapeutic benefits. Multiparticulate dosage forms such as Microballons are pharmaceutical formulations in which the active substance is present as a number of small independent subunits with diameter of 0.05-2.00 mm and widely accepted as a means to achieve oral and parenteral controlled release.Ondansetron hydrochloride, a 5 HT3 antagonist, is a powerful antiemetic drug which has oral bioavailability of 60% due to hepatic first pass metabolism and has a short half-life of 5 h... It is commonly used in treatment of chemotherapy associated emesis.