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There are many unclear mechanisms regarding the pathogenesis of Alzheimer's disease (AD) and no form of prevention or cure. It is known that in the development of the disease, microglia can undergo phenotypic changes and that this can directly influence neurons. In order to understand more about the neuroimmune interactions that exist in Alzheimer's disease, this project's main objective is to investigate when and how the change from M2 to M1 microglia occurs in the triple transgenic model (3xTg-AD), the murine model that most closely resembles the disease in humans. This pattern change…mehr

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Produktbeschreibung
There are many unclear mechanisms regarding the pathogenesis of Alzheimer's disease (AD) and no form of prevention or cure. It is known that in the development of the disease, microglia can undergo phenotypic changes and that this can directly influence neurons. In order to understand more about the neuroimmune interactions that exist in Alzheimer's disease, this project's main objective is to investigate when and how the change from M2 to M1 microglia occurs in the triple transgenic model (3xTg-AD), the murine model that most closely resembles the disease in humans. This pattern change reflects neurodegeneration and is related to beta-amyloid plaques and neurofibrillary tangles. We know that increased production of reactive oxygen species (ROS) accompanies the change from the M2 to M1 phenotype, which is responsible for the release of pro-inflammatory cytokines that can be directly toxic to neurons. Therefore, we want to know when this occurs and what mechanism is involved in the change in the activation pathway of microglia from the alternative phenotype (M2) to the classic phenotype (M1) in 3xTg-AD mice, triple transgenic for AD.
Autorenporträt
Marina Zanichelli Barbosa jest absolwentk¿ nauk biomedycznych na Uniwersytecie Stanowym Paulista "Júlio de Mesquita Filho". Prowadzi¿a badania naukowe w dziedzinie dystrofii mi¿¿niowej Duchenne'a (Wydziä Anatomii/UNESP Botucatu) oraz choroby Alzheimera (ICB/USP). Posiada uprawnienia w zakresie obrazowania medycznego i badania kliniczne.