Micronized carvedilol SR matrix tablet for imporved dissolution - Chatterjee, Bappaditya
24,99 €
inkl. MwSt.
Versandkostenfrei*
Versandfertig in 6-10 Tagen
payback
12 °P sammeln
  • Broschiertes Buch

Carvedilol, a BCS class II beta blocker drug is formulated as a SR matrix tablet with micronized drug particle. Micronization helps improve dissolution and enhances systemic absorption for BCS II drugs such as carvedilol.Direct compression method was applied to prepare tablet using PEO 301 as a release retardant polymer. The formulation was optimized by a 3 level factorial design considering amount of PEO 301 and hardness of tablet as dependent variables. In-vitro release study showed near about 100% of drug release in 12 hrs. for lowest particle size drug whereas for non-micronized drug it was less than 80%.…mehr

Andere Kunden interessierten sich auch für
Produktbeschreibung
Carvedilol, a BCS class II beta blocker drug is formulated as a SR matrix tablet with micronized drug particle. Micronization helps improve dissolution and enhances systemic absorption for BCS II drugs such as carvedilol.Direct compression method was applied to prepare tablet using PEO 301 as a release retardant polymer. The formulation was optimized by a 3 level factorial design considering amount of PEO 301 and hardness of tablet as dependent variables. In-vitro release study showed near about 100% of drug release in 12 hrs. for lowest particle size drug whereas for non-micronized drug it was less than 80%.
Autorenporträt
Bappaditya Chatterjee (PhD), dottore in Farmacia presso l'Università di Jadavpur, India, è attualmente assegnato al Dipartimento di Tecnologia Farmaceutica dell'IIUM, Malesia, come assistente professore con l'ulteriore responsabilità di capo del reparto R&S dell'IKOP Sdn. Bhd. Negli ultimi 5 anni ha pubblicato più di 30 articoli su riviste di grande impatto.