The first reports on the application of microwaves in organic synthesis date back to 1986, but it was not until the recent introduction of specifically designed and constructed equipment, which countered the safety and reproducibility concerns, that synthetic application of microwaves has become established as a laboratory technique. Microwave assisted synthesis is now being adopted in many industrial and academic laboratories to take advantage of the novel chemistry that can be carried out using a variety of organic reaction types.
This book demonstrates the underlying principles of microwave dielectric heating and, by reference to a range of organic reaction types, it’s effective use in synthetic organic chemistry. To illustrate the impact microwave assisted organic
Contents
Theoretical aspects of microwave dielectric heating; Microwave-assisted solid-phase synthesis; Microwave accelerated metal catalysis organic transformations at warp speed; Microwave assisted reductions; Highly efficient synthesis techniques using microwave irradiation; The impact of microwave assited organic synthesis on high throughput chemistry; Heterocyclic chemistry using microwave assisted approaches; Microwave assisted use polymer supported reagents in synthesis; Scale-up issues in microwave assisted organic synthesis; Lead optimization using microwave assisted organic synthesis
This book demonstrates the underlying principles of microwave dielectric heating and, by reference to a range of organic reaction types, it’s effective use in synthetic organic chemistry. To illustrate the impact microwave assisted organic
Contents
Theoretical aspects of microwave dielectric heating; Microwave-assisted solid-phase synthesis; Microwave accelerated metal catalysis organic transformations at warp speed; Microwave assisted reductions; Highly efficient synthesis techniques using microwave irradiation; The impact of microwave assited organic synthesis on high throughput chemistry; Heterocyclic chemistry using microwave assisted approaches; Microwave assisted use polymer supported reagents in synthesis; Scale-up issues in microwave assisted organic synthesis; Lead optimization using microwave assisted organic synthesis