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Cancer poses a growing public health crisis in Vietnam, necessitating data-driven interventions. This study utilized Globocan 2018 estimates and mathematical modeling to analyze cancer incidence, mortality, and risk. Key parameters are based on the estimated 164,671 new cases and 114,871 deaths in 2018. Marked sex-specific patterns emerged: Liver, Lung, and Stomach cancers drive the burden in males, while Breast, Colorectum, and Lung cancers predominate in females. Vietnam's Age-Standardized Mortality Rate (ASMR) is high at 104.4 per 100,000, particularly elevated in males (146.2/100,000). Notably, Vietnam exhibits a high Age-Standardized Mortality Rate (ASMR) of 104.4 per 100,000 populations, which is particularly elevated in males (146.2/100,000). The established quantitative framework and correlation models provide crucial data-driven foundations for prioritizing resource allocation, developing highly targeted cancer prevention strategies, and enhancing early detection programs specific to Vietnam's unique demographic and epidemiological profile.