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In this study, novel phthalonitriles 3,13,14 and their corresponding metal-free 4 and metallo phthalocyanine derivatives (5,6,7,15,16,17,18) bearing differents groups were synthesized and characterized. 3,4-dihydropyrimidinones have been synthesized in good yields by a modified Biginelli-type reaction with various metallophthalocyanines 8-23 as catalysts. Among the various metallophthalocyanines studied, cobalt(II)- phthalocyanine was found to be most active for this transformation. The newly prepared compounds were characterized using elemental analyses,MS, IR, 1H/13C NMR, and UV-vis…mehr

Produktbeschreibung
In this study, novel phthalonitriles 3,13,14 and their corresponding metal-free 4 and metallo phthalocyanine derivatives (5,6,7,15,16,17,18) bearing differents groups were synthesized and characterized. 3,4-dihydropyrimidinones have been synthesized in good yields by a modified Biginelli-type reaction with various metallophthalocyanines 8-23 as catalysts. Among the various metallophthalocyanines studied, cobalt(II)- phthalocyanine was found to be most active for this transformation. The newly prepared compounds were characterized using elemental analyses,MS, IR, 1H/13C NMR, and UV-vis spectroscopy. In addition; the 3,4-dihydropyrimidinones 8-12 were investigated for anti-oxidant activities by super oxide radical; DPPH (2,2-Diphenyl-1-picrylhydrazyl); and hydroxyl radical scavenging assays; in which most of them displayed significant antioxidant activities. Furthermore; compounds 8-12 were evaluated for anti-inflammatory activity by indirect haemolytic and lipoxygenase inhibition assays and revealed good activity.
Autorenporträt
Naceur Hamdi est professeur associé de chimie à l'université de Carthage (Isste de Borj Cedria), en Tunisie. J'ai publié plus de 60 articles dans des revues internationales, dont trois chapitres de livres. Mes principaux domaines de recherche sont la chimie verte, les transformations par catalyse homogène telles que la métathèse des oléfines et les réactions d'oxydation.