Modulation of Cardiac Gene Expression Profiles - Bleiblo, Farag; Eljaki, Abdelhakim; Elwaheishi, Khaled
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Cardiac myocyte dysfunction is clearly identified as underlying the acute heart failure associated with bacterial infections, sepsis, as well as chronic syndrome following cardiac damage. Cardiac myocytes express functional TLRs and sense PAMPs directly. Although the immunostimulatory potential and receptor-mediated recognition of single stranded RNA (ssRNA) are well documented, no comprehensive analysis of gene expression in response to natutrally occurring bacterial RNA or modified ssRNA has been reported. Using cDNA Microarrays, we have analyzed the gene expression profiles of human adult cardiac myocytes stimulated with S. aureus RNA.…mehr

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Produktbeschreibung
Cardiac myocyte dysfunction is clearly identified as underlying the acute heart failure associated with bacterial infections, sepsis, as well as chronic syndrome following cardiac damage. Cardiac myocytes express functional TLRs and sense PAMPs directly. Although the immunostimulatory potential and receptor-mediated recognition of single stranded RNA (ssRNA) are well documented, no comprehensive analysis of gene expression in response to natutrally occurring bacterial RNA or modified ssRNA has been reported. Using cDNA Microarrays, we have analyzed the gene expression profiles of human adult cardiac myocytes stimulated with S. aureus RNA.
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Autorenporträt
Le Dr Bleiblo a obtenu son doctorat en sciences biomoléculaires à l'Université Laurentienne/Canada. Il est actuellement professeur associé de biologie moléculaire et de virologie à l'Université de Benghazi/Libye. Farag a obtenu une subvention de renforcement des capacités de recherche du NSREC pour l'excellence de sa recherche et une bourse canadienne pour étudiants. En tant que chercheur, il a publié de nombreux travaux.