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This book explores the relationship between gut microbiota and depression, highlighting the efficacy of non-pharmacological interventions such as cognitive-behavioral therapy, exercise and nutrition. Through a comprehensive review of the literature, new perspectives are offered for the treatment of mental disorders, promoting continued research in this field.Research in the field of mental health and gut microbiota has gained unprecedented relevance in recent years, driven by the growing understanding of the complex relationship between psychological well-being and gut health. This book is presented as an effort to compile and analyze the current evidence on the efficacy of nonpharmacological interventions in modulating the gut microbiota and its impact on depression. The importance of this research lies not only in its potential to transform clinical practice, but also in its ability to offer new perspectives on the treatment of mental disorders that affect millions of people worldwide.