Molecular Basis of Breast Cancer - Russo, Jose;Russo, Irma H.
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book, whose goal is to comprehensively review in ten During the past 30 years we have witnessed the emer chapters the fundamental knowledge on breast can gence of new disciplines whose contribution to the understanding of the biology of breast cancer have cer. The opening chapter links epidemiology, influ been enormous. Advances in the field of steroid hor ence of geographic and environmental exposures on mone nuclear receptors, which control the expression cancer incidence to the development of the organ and of genetic programs involved in cellular processes its role in cancer initiation.…mehr

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Produktbeschreibung
book, whose goal is to comprehensively review in ten During the past 30 years we have witnessed the emer chapters the fundamental knowledge on breast can gence of new disciplines whose contribution to the understanding of the biology of breast cancer have cer. The opening chapter links epidemiology, influ been enormous. Advances in the field of steroid hor ence of geographic and environmental exposures on mone nuclear receptors, which control the expression cancer incidence to the development of the organ and of genetic programs involved in cellular processes its role in cancer initiation. Central to this approach that are essential for normal and aberrant cell is the endocrine control of breast development, the growth, have been major contributors to the therapy relationship of cell proliferation with the presence of and prevention of hormone-dependent cancers. The steroid hormone receptors in the breast epithelium, and finally the importance of full differentiation as a discoveries of the association of hereditary breast cancers with mutations in the BRCAl and BRCA2 tool for protecting the breast from developing cancer. genes, and the concept that they essentially represent Reported are studies of the pathogenesis of breast a continuum of mutations with different degrees of cancer that have elucidated the site of origin of breast penetrance within given families, have added consid cancer and have been validated by in vitro experi erable understanding to the molecular basis of breast mentation.
Autorenporträt
Jose Russo, M.D., FACP is a Professor and Senior Member for the Fox Chase Cancer Center. He is also the Director of the Breast Cancer and Environment Research Center at Fox Chase .In addition to his roles at Fox Chase, he is simultaneously an Adjunct Professor of Pathology and Cell Biology at Jefferson Medical College, as well as an Adjunct Professor of Biochemistry at Temple Medical School. His primary research interest includes breast cancer, endocrinology, hormonal and environmental carcinogenesis. He's received several academic and research awards for his outstanding work in the field. He's a member of numerous scientific and professional societies. He has published over 350 scientific papers. He also serves on several editorial boards for several journals including, International Journal of Oncology, Hormone Molecular Biology and Clinical Investigation, and the Journal of Medical Hypothesis and Research. In addition, he's the editor-in-chief of the Journal of Women's Cancer. He's also published several books with Springer in the past. Irma Russo, M.D., FACP, FASCP is Associate Professor at the Fox Chase Cancer Center and the Chief of the Molecular Endocrinology Section oat the Breast Cancer Research Lab. She has over 190 scientific publications.
Rezensionen
From the reviews:

"This book provides the scientific basis for a new paradigm according to which breast cancer prevention and treatment should be developed. The book is unique in that it is based on an understanding of the developmental pattern of the breast in rodents and humans." (Biomedicine & Pharmacotherapy, Vol. 58, 2004)

"This is a comprehensive and detailed textbook which covers all the fundamental areas of knowledge on breast cancer. ... This text provides an excellent reference book for anyone involved in this field ... . For those wanting an in-depth knowledge of this rapidly expanding field, this is easy to read and tackles complex theories very successfully with excellent illustrations to all chapters." (Erika Denton, RAD Magazine, September, 2004)

"Molecular Basis of Breast Cancer provides a window through which to view some future strategies in the prevention of breast cancer. This richly illustrated book has a unique focus and original perspective. ... The broad summary of the scientific literature on this area of research strongly adds value to the book." (Robert B. Dickson, The New England Journal of Medicine, Issue 9, 2004)