Extensively updated, the new edition of this pioneering textbook for Molecular Medicine covers 14 modules from molecular diagnostics to precision medicine approaches, stem cells, and gene therapy.
Extensively updated, the new edition of this pioneering textbook for Molecular Medicine covers 14 modules from molecular diagnostics to precision medicine approaches, stem cells, and gene therapy.
Jens Kurreck, PhD, is a full Professor for Applied Biochemistry at the Berlin University of Technology (TUB), Germany. He studied biochemistry and philosophy at the Free University of Berlin (FUB) and completed his PhD at the TUB in 1998. His research focuses on RNA technologies, pain research and virology. Cy Aaron Stein, PhD, is Professor of Oncology and Experimental Therapeutics at the City of Hope Medical Center in Duarte, CA, USA. He received a PhD in chemistry from Stanford University and an MD degree at the Albert Einstein College of Medicine, NY, in 1982. He has received numerous awards, among them the Clinical Career Development Award of the American Cancer Society.
Inhaltsangabe
1 Introduction 1.1 The Basics of Molecular Medicine 1.2 The Human Cell 1.3 DNA Replication and Gene Expression 1.4 Biological Communication 1.5 The Immune System 2 Methods in Molecular Medicine 2.1 DNA Microarrays 2.2 Quantitative Polymerase Chain Reaction 2.3 Next-Generation Sequencing 2.4 Proteomics 2.5 Animal Models in Biomedical Research 2.6 Alternatives to Animal Testing 2.7 Additional Methods 3 Genetic Disorders 3.1 Single-Gene Disorders 3.2 Polygenic Disorders 4 Molecular Oncology 4.1 Basics of Oncology 4.2 Selected Cancer Diseases 4.3 Oncolytic Virus Therapy 4.4 Cancer Stem Cells 4.5 Cancer Immunotherapy 5 Molecular Virology 5.1 The Basics of Virology 5.2 Vaccination 5.3 Detection of Viruses 5.4 Antiviral Therapy 5.5 Prions 6 Bacteria and Eukaryotic Pathogens 6.1 Bacteria 6.2 Eukaryotic Pathogens 7 Genomics and Proteomics 7.1 Whole Genome Sequencing 7.2 The Human Genome 7.3 Sequencing of Ancient DNA 7.4 Follow-up Initiatives of the Human Genome Project 8 Genetic Testing 8.1 Types of Genetic Tests 8.2 Chromosome Abnormalities 8.3 Molecular Diagnosis 9 Pharmacogenetics/Pharmacogenomics 9.1 Uptake and Transport of Drugs 9.2 Drug Metabolism 9.3 Drug Targeting 9.4 Drug Toxicity and Hypersensitivity 9.5 Drug Development and Individual Pharmacotherapy 10 Recombinant Protein Drugs 10.1 Production of Recombinant Proteins 10.2 Classes of Recombinant Drugs 11 Gene Therapy 11.1 Types of Gene Therapy 11.2 Methods of Gene Transfer 11.3 Tissue Specificity of Gene Transfer and Gene Expression 11.4 Applications of Gene Therapy 11.5 Genome Editing with CRISPR/Cas 11.6 Future Prospects 12 Stem Cells 12.1 Embryonic Stem Cells 12.2 Adult Stem Cells 12.3 Induced Pluripotent Stem Cells 12.4 Transdifferentiation and Direct Reprogramming 12.5 Differentiation of Stem Cells 12.6 Medical Applications of Stem Cells 13 Oligonucleotide-based Strategies 13.1 Antisense Oligonucleotides 13.2 RNA Interference 13.3 MicroRNAs 13.4 Aptamers, Decoy Oligonucleotides, and Immunostimulatory Oligonucleotides 14 Ethics in Molecular Medicine 14.1 The Basis of Bioethics 14.2 Fields of Application
1 Introduction 1.1 The Basics of Molecular Medicine 1.2 The Human Cell 1.3 DNA Replication and Gene Expression 1.4 Biological Communication 1.5 The Immune System 2 Methods in Molecular Medicine 2.1 DNA Microarrays 2.2 Quantitative Polymerase Chain Reaction 2.3 Next-Generation Sequencing 2.4 Proteomics 2.5 Animal Models in Biomedical Research 2.6 Alternatives to Animal Testing 2.7 Additional Methods 3 Genetic Disorders 3.1 Single-Gene Disorders 3.2 Polygenic Disorders 4 Molecular Oncology 4.1 Basics of Oncology 4.2 Selected Cancer Diseases 4.3 Oncolytic Virus Therapy 4.4 Cancer Stem Cells 4.5 Cancer Immunotherapy 5 Molecular Virology 5.1 The Basics of Virology 5.2 Vaccination 5.3 Detection of Viruses 5.4 Antiviral Therapy 5.5 Prions 6 Bacteria and Eukaryotic Pathogens 6.1 Bacteria 6.2 Eukaryotic Pathogens 7 Genomics and Proteomics 7.1 Whole Genome Sequencing 7.2 The Human Genome 7.3 Sequencing of Ancient DNA 7.4 Follow-up Initiatives of the Human Genome Project 8 Genetic Testing 8.1 Types of Genetic Tests 8.2 Chromosome Abnormalities 8.3 Molecular Diagnosis 9 Pharmacogenetics/Pharmacogenomics 9.1 Uptake and Transport of Drugs 9.2 Drug Metabolism 9.3 Drug Targeting 9.4 Drug Toxicity and Hypersensitivity 9.5 Drug Development and Individual Pharmacotherapy 10 Recombinant Protein Drugs 10.1 Production of Recombinant Proteins 10.2 Classes of Recombinant Drugs 11 Gene Therapy 11.1 Types of Gene Therapy 11.2 Methods of Gene Transfer 11.3 Tissue Specificity of Gene Transfer and Gene Expression 11.4 Applications of Gene Therapy 11.5 Genome Editing with CRISPR/Cas 11.6 Future Prospects 12 Stem Cells 12.1 Embryonic Stem Cells 12.2 Adult Stem Cells 12.3 Induced Pluripotent Stem Cells 12.4 Transdifferentiation and Direct Reprogramming 12.5 Differentiation of Stem Cells 12.6 Medical Applications of Stem Cells 13 Oligonucleotide-based Strategies 13.1 Antisense Oligonucleotides 13.2 RNA Interference 13.3 MicroRNAs 13.4 Aptamers, Decoy Oligonucleotides, and Immunostimulatory Oligonucleotides 14 Ethics in Molecular Medicine 14.1 The Basis of Bioethics 14.2 Fields of Application
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