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Ischemic demyelination was once considered as a nugatory finding on Brain MRIs with uncertain clinical importance. Nevertheless, currently it's an entity with emerging clinical significance concerning with its coexistence with ischemic infarct rising the possibility of homologous pathogenesis, as a risk factor for development of ischemic infarct and with its association with cognitive dysfunction. This book deals with MR imaging of ischemic demyelination and its upcoming clinical essence in detail.