Mutational Analysis in Patients with Uveal Melanomas - Mai, Yuehua
40,99 €
inkl. MwSt.
Versandkostenfrei*
Versandfertig in 6-10 Tagen
payback
20 °P sammeln
  • Broschiertes Buch

There is no standard treatment for the advanced and metastatic uveal melanoma so far, genotypic characterization of uveal melanoma might identify patients who could benefit from a drug-target based approach. In our study, mutations in genes GNAQ and GNA11, BRAF, NRAS, and KIT in primary and matched metastatic uveal melanoma specimens were evaluated. Statistical analysis was carried out to evaluate correlation between mutational status and clinico-pathological parameters. Results from this study showed 85.5% of primary uveal melanomas have mutations either in GNAQ or GNA11. No association was…mehr

Andere Kunden interessierten sich auch für
Produktbeschreibung
There is no standard treatment for the advanced and metastatic uveal melanoma so far, genotypic characterization of uveal melanoma might identify patients who could benefit from a drug-target based approach. In our study, mutations in genes GNAQ and GNA11, BRAF, NRAS, and KIT in primary and matched metastatic uveal melanoma specimens were evaluated. Statistical analysis was carried out to evaluate correlation between mutational status and clinico-pathological parameters. Results from this study showed 85.5% of primary uveal melanomas have mutations either in GNAQ or GNA11. No association was found between mutational status and prognostic parameters. GNAQ or GNA11 mutations are common in metastases, but further mutations can be acquired suggestive of cancer clonal evolution.
Autorenporträt
Yuehua Mai, Board certified Ophthalmologist, Doctor degree of Medicine: 2002 - 2007 Bachelor Title of Clinical Medicine; 2007 - 2010 Master Title of Ophthalmology; 2010 - 2015 Doctor Title of Doctor Medicinae from Medical Faculty of Charité-Universitätsmedizin Berlin, Germany