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In the field of endodontics, exploring the properties and clinical applications of nanoparticles is opening up promising new perspectives.Our work focuses on the potential of key components such as chitosan, silver, graphene, metal oxides, gold, bioactive glass, hydroxyapatite and zirconia.Nanoparticles are revolutionizing endodontics by offering a promising range of clinical applications, such as: pulp vitality preservation, endodontic irrigation, endodontic instrumentation, intracanal medication, root canal obturation, pulp regeneration, and coronal obturation materials (composite resins, glass ionomer cements and dental adhesives).Despite the promising potential of nanoparticles in endodontics, it is crucial to stress that research in this field is still in its infancy. The majority of studies currently being carried out are limited to in vitro investigations, making it impossible to fully assess their efficacy and safety in a real-life clinical context. It is imperative to conduct rigorous clinical studies with a high level of scientific proof.