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Chronic rhinosinusitis, with or without polyps, is one of the world's most common conditions, affecting around 14% of people in the USA.Nasosinus polyposis is a chronic rhinosinusitis characterized by multifocal, bilateral edematous degeneration of the mucosa of the lateral masses of the ethmoid. These polyps are the result of chronic inflammation of the nasosinus mucosa, with eosinophilic infiltration characteristic of the disease. Its pathophysiology remains poorly understood, and several studies and theories have attempted, and continue to attempt, to explain it. This obscure pathophysiology makes the aims of treatment, whether medical or surgical, not to cure this pathology, but rather to improve symptoms and quality of life for these patients.