Wan Nazirah Wan Yusuf

NAT2 Polymorphisms in Malays, Chinese and Indians in Malaysia

NAT2 pharmacogenetics

• Broschiertes Buch

Produktbeschreibung

NAT2 is polymorphic. It gives rise to acetylator status that may influence pharmacotherapy and carcinogenesis. The polymorphisms was studied in Malaysia before using methods that were not specific. We reinvestigated NAT2 polymorphisms in Malaysia using more specific methods. Correlation between NAT2 genotypes and isoniazid metabolic ratio was of moderate significance. Our results differed from the previous Malaysian study in terms of allele frequencies, but similar ethnic differences were observed. Our data provides a useful baseline of NAT2 polymorphisms in Malaysia that can help planning of further studies of the polymorphisms in Malaysia especially as they relate to pharmacotherapy and environmentally induced cancers. Our study also showed the importance of using appropriate genotyping methods to define population polymorphisms

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 204
• Englisch
• Gewicht: 279g
• ISBN-13: 9783639212709
• ISBN-10: 3639212703
• Artikelnr.: 27886201

Autorenporträt

MD (USM), MSc (Molecular Medicine) is senior lecturer at the Medical School, Universiti Sains Malaysia (USM) and a member of the Pharmacogenetics Research Group at the Institute for Research in Molecular Medicine (INFORMM),USM. Her interests include pharmacogenetics and pharmacology especially as it pertains to HIV/AIDS and co-infections.