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Providing a summary of recent research, this book makes the case that DOPA meets many of the criteria of neurotransmitters. It begins with a historical review, followed by a look at the essential criteria of a neurotransmitter. Experts in the field summarize the issues surrounding DOPA neurotoxicity and explore the link between experimental studies and clinical relevance. They examine metabolism with regard to catecholamine synthesis, and degradation products related to neuron death. They also discuss recognition and transport sites, the physiological release of DOPA, responses involved in baroreflex neurotransmission, and interactions with catecholamines, acetylcholine, glutamate, and GABA.