Neurology is a complex field with many nuances specific to individual patients. Each patient's neurological condition can present uniquely, influenced by a myriad of factors such as genetics, lifestyle, comorbidities, and environmental exposures. This complexity means the traditional method of learning medicine by subject matter often fails to capture the essence of real-world clinical practice. Like all skills, proficiency in neurology is acquired through mindful practice. This involves deep analysis of each case, corrected in real-time by gold standards such as genetic tests, imaging, and…mehr
Neurology is a complex field with many nuances specific to individual patients. Each patient's neurological condition can present uniquely, influenced by a myriad of factors such as genetics, lifestyle, comorbidities, and environmental exposures. This complexity means the traditional method of learning medicine by subject matter often fails to capture the essence of real-world clinical practice. Like all skills, proficiency in neurology is acquired through mindful practice. This involves deep analysis of each case, corrected in real-time by gold standards such as genetic tests, imaging, and pathology. To maintain and expand one's expertise, this process must be continually practiced throughout one's career. Neurology: One Patient at a Time is a collection of clinical commentaries written by Dr. Martin A. Samuels based on cases covered in the daily "Morning Report", which he initiated in the department of Neurology at Brigham and Women's. Each case is meticulously analyzed, with relevant references to literature and his personal judgment as one of the world's leading neurologists. This blend of evidence-based concepts and expert interpretation allows for a more holistic approach to patient care. Containing more than 70 representative patient cases, Neurology: One Patient at a Time provides invaluable insights for trainees and experts alike.
Martin A. Samuels, MD, FAAN, MACP, FRCP, DSci (hon.), was a renowned neurologist and the founding Chairman of the Neurology Department at Brigham and Women's Hospital in Boston, MA. He held the Miriam Sydney Joseph Distinguished Chair for Professor of Neurology at Harvard Medical School and was a recipient of the National Clinical Excellence Award from Johns Hopkins University, the Bicentennial Medal from Williams College, and the Distinguished Alumni Award from the University of Cincinnati College of Medicine, among many others. Dr. Samuels was board certified in both Internal Medicine and Neurology and was a Master of the American College of Physicians, a Fellow of the American Academy of Neurology, and a member of The American Neurological Association, and the Royal College of Physicians, London. He created the Manual of Neurologic Therapeutics and was incredibly influential to the development of the field of neurological medicine in the interface between internal medicine and neurology.
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* Preface * Section 01: Cerbrovascular Diseases * Case 1: Convexity Hemorrhage and RCVS: "Did She Fall or Was She Pushed?" * Case 2: Left Pontine Infarct (Not a Lacune) After a Diagnosis of FND * Case 3: Radiation Vascular Disease Causing Pontine Strokes: The Gift That Keeps on Giving * Case 4: Dental Numbness and the Quintothalamic Tract * Case 5: Multiple Saccular Aneurysms * Case 6: Budd-Chiari and Cortical Vein Thrombosis * Case 7: Vermal Arteriovenous Malformation * Case 8: Orthostatic Shaking * Section 02: Cognitive and Behavioral Disorders * Case 9: Aphasia and the Insula * Case 10: Transient Global Amnesia * Case 11: Anton-Babinski in Reverse and Denial of Seeing * Case 12: Confusional State * Section 03: Movement Disorders * Case 13: Multiple-System Atrophy, Parkinsonian Subtype (Shy-Drager Syndrome) * Case14: Parkinsonism Perioperative Delirium * Case 15: Chorea Gravidarum and Acanthocytosis * Case 16: Psychogenic Overlay * Section 04: Seizure Disorders * Case 17: ALL Treatment and Epilepsia Partialis Continua * Case 18: First Seizure and a Right Parietal Lesion in a 65-Year-Old Pilot * Case19: Cursive Seizures and Epileptic Personality * Section 05: Neoplastic Disorders * Case 20: Glioblastoma Producing Transcortical Motor Aphasia * Case 21: Lymphomatoid Granulomatosis * Case 22: Hydrocephalus from Pineal Region Glioma * Case 23: Herniation * Case 24: Subacute Encephalopathy in a Woman with "Gastric Cancer" * Cas 25: Cauda Equina Syndrome in an Immunocompromised Patient * Case 26: Pituitary Apoplexy * Case 27: Charles Bell X 2: Facial Palsy and Mental Numbness * Case 28: I Missed a Glioma * Case 29: Lymphoma * Section 06: Headache and Pain * Case 30: CREST Neurology and Convexity Subarachnoid Hemorrhage * Case 31: Complicated Migraine with Cerebral Venous Thrombosis * Case 32: Migrainous White Spots * Case 33: Acute Eye Pain * Case 34: Migraine in the Elderly * Case 35: Migraine: The Neurologist's Friend * Section 07: Peripheral Nervous System Disorders * Case 36: Amyloid Neuropathy * Case 37: Weak in the ICU: Neurocritical Care Neuromyopathy * Case 38: Microvascular Oculomotor Palsy * Case 39: Nemaline Myopathy * Case 40: Duchenne Dystrophy and Chronic Hypoxia * Case 41: Necrotizing Statin Myopathy * Section 08: Metabolic and Toxic Disorders * Case 42: Metabolic Encephalopathy from Osmotic Shifts * Section 09: Psychogenic Disorders * Case 43: Psychogenic Weakness on the Left Side * Case 44: MELAS + Stress * Case 45: A Dissociative State * Case 46: The Perils of FND * Case 47: The DTs Return * Case 48: Psychogenic Paraplegia * Section 10: Spinal Fluid Disorders * Case 49: The Froin-Nonne Sign * Case 50: "A Thick Chart Means It's Either Psychogenic or a Syrinx" H. Houston Merrett * Section 11: Medical Neurology * Case 51: Neurocardiac Lesion * Case 52: Trousseau's Disease * Case 53: Cobalamin Deficiency * Case 54: Trousseau's Syndrome with Pancreatic Cancer * Case 55: Cardiac Surgery-Related Stroke * Case 56: ECMO and Migraine * Case 57: Myeloproliferative Disorders, Hyperviscosity and Pseudo-dissection * Section 12: Infectious Diseases * Case 58: Orbital Cellulitis With Superior Ophthalmic Vein Thrombophlebitis * Case 59: Antibiotic Neurotoxicity * Case 60: Leptomeningitis and Ventriculitis in a Patient on Steroids * Case 61: Neutrophilic Meningoencephalitis * Case 62: Infective Endocarditis * Case 63: Lightning Pains * Case 64: Hodgkin Disease, Stem Cell Transplant and Recurrent Encephalitis * Section 13: Immune and Inflammatory Disorders * Case 65: MS Acute Treatment and Disease Modifying Therapies (DMTs) * Case 66: A Fatal Demyelinating Disease * Case 67: One-and-a-Half Syndrome * Case 68: Autoimmune Encephalitis * Section 14: Dizziness * Case 69: Chronic Dizziness and the Syndrome of Multiple Sensory Deficits * Section 15: Spinal Cord Disorders * Case 70: Cervical Myelopathy * Case 71: Myelopathy After Minor Accident * Case 72: Cervical Spondylosis in an 81-Year-Old Woman
* Preface * Section 01: Cerbrovascular Diseases * Case 1: Convexity Hemorrhage and RCVS: "Did She Fall or Was She Pushed?" * Case 2: Left Pontine Infarct (Not a Lacune) After a Diagnosis of FND * Case 3: Radiation Vascular Disease Causing Pontine Strokes: The Gift That Keeps on Giving * Case 4: Dental Numbness and the Quintothalamic Tract * Case 5: Multiple Saccular Aneurysms * Case 6: Budd-Chiari and Cortical Vein Thrombosis * Case 7: Vermal Arteriovenous Malformation * Case 8: Orthostatic Shaking * Section 02: Cognitive and Behavioral Disorders * Case 9: Aphasia and the Insula * Case 10: Transient Global Amnesia * Case 11: Anton-Babinski in Reverse and Denial of Seeing * Case 12: Confusional State * Section 03: Movement Disorders * Case 13: Multiple-System Atrophy, Parkinsonian Subtype (Shy-Drager Syndrome) * Case14: Parkinsonism Perioperative Delirium * Case 15: Chorea Gravidarum and Acanthocytosis * Case 16: Psychogenic Overlay * Section 04: Seizure Disorders * Case 17: ALL Treatment and Epilepsia Partialis Continua * Case 18: First Seizure and a Right Parietal Lesion in a 65-Year-Old Pilot * Case19: Cursive Seizures and Epileptic Personality * Section 05: Neoplastic Disorders * Case 20: Glioblastoma Producing Transcortical Motor Aphasia * Case 21: Lymphomatoid Granulomatosis * Case 22: Hydrocephalus from Pineal Region Glioma * Case 23: Herniation * Case 24: Subacute Encephalopathy in a Woman with "Gastric Cancer" * Cas 25: Cauda Equina Syndrome in an Immunocompromised Patient * Case 26: Pituitary Apoplexy * Case 27: Charles Bell X 2: Facial Palsy and Mental Numbness * Case 28: I Missed a Glioma * Case 29: Lymphoma * Section 06: Headache and Pain * Case 30: CREST Neurology and Convexity Subarachnoid Hemorrhage * Case 31: Complicated Migraine with Cerebral Venous Thrombosis * Case 32: Migrainous White Spots * Case 33: Acute Eye Pain * Case 34: Migraine in the Elderly * Case 35: Migraine: The Neurologist's Friend * Section 07: Peripheral Nervous System Disorders * Case 36: Amyloid Neuropathy * Case 37: Weak in the ICU: Neurocritical Care Neuromyopathy * Case 38: Microvascular Oculomotor Palsy * Case 39: Nemaline Myopathy * Case 40: Duchenne Dystrophy and Chronic Hypoxia * Case 41: Necrotizing Statin Myopathy * Section 08: Metabolic and Toxic Disorders * Case 42: Metabolic Encephalopathy from Osmotic Shifts * Section 09: Psychogenic Disorders * Case 43: Psychogenic Weakness on the Left Side * Case 44: MELAS + Stress * Case 45: A Dissociative State * Case 46: The Perils of FND * Case 47: The DTs Return * Case 48: Psychogenic Paraplegia * Section 10: Spinal Fluid Disorders * Case 49: The Froin-Nonne Sign * Case 50: "A Thick Chart Means It's Either Psychogenic or a Syrinx" H. Houston Merrett * Section 11: Medical Neurology * Case 51: Neurocardiac Lesion * Case 52: Trousseau's Disease * Case 53: Cobalamin Deficiency * Case 54: Trousseau's Syndrome with Pancreatic Cancer * Case 55: Cardiac Surgery-Related Stroke * Case 56: ECMO and Migraine * Case 57: Myeloproliferative Disorders, Hyperviscosity and Pseudo-dissection * Section 12: Infectious Diseases * Case 58: Orbital Cellulitis With Superior Ophthalmic Vein Thrombophlebitis * Case 59: Antibiotic Neurotoxicity * Case 60: Leptomeningitis and Ventriculitis in a Patient on Steroids * Case 61: Neutrophilic Meningoencephalitis * Case 62: Infective Endocarditis * Case 63: Lightning Pains * Case 64: Hodgkin Disease, Stem Cell Transplant and Recurrent Encephalitis * Section 13: Immune and Inflammatory Disorders * Case 65: MS Acute Treatment and Disease Modifying Therapies (DMTs) * Case 66: A Fatal Demyelinating Disease * Case 67: One-and-a-Half Syndrome * Case 68: Autoimmune Encephalitis * Section 14: Dizziness * Case 69: Chronic Dizziness and the Syndrome of Multiple Sensory Deficits * Section 15: Spinal Cord Disorders * Case 70: Cervical Myelopathy * Case 71: Myelopathy After Minor Accident * Case 72: Cervical Spondylosis in an 81-Year-Old Woman
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