New route to the synthesis of chiral 1,2,4-oxadiazin-5-ones - TKA, Najeh
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The research work carried out in this book aims to develop a simple and rapid synthesis route for new chiral derivatives of 1,2,4-oxadiazin-5-ones known for their interesting biological activities.The first part of this book describes the synthesis of a series of optically active -bromoacids by enantioselective nitrous deamination of natural amino acids. These will subsequently react with thionyl chloride followed by methanol to give the corresponding -bromoesters.Condensation of these previously prepared -bromoesters with 1-benzenesulfonylpyrrolidin-2-carboxamidoxime in the presence of two…mehr

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Produktbeschreibung
The research work carried out in this book aims to develop a simple and rapid synthesis route for new chiral derivatives of 1,2,4-oxadiazin-5-ones known for their interesting biological activities.The first part of this book describes the synthesis of a series of optically active -bromoacids by enantioselective nitrous deamination of natural amino acids. These will subsequently react with thionyl chloride followed by methanol to give the corresponding -bromoesters.Condensation of these previously prepared -bromoesters with 1-benzenesulfonylpyrrolidin-2-carboxamidoxime in the presence of two equivalents of sodium hydride offers desired new chiral 1,2,4-oxadiazin-5-ones in good chemical yields.
Autorenporträt
Il dottor Najeh TKA è un professore assistente qualificato che lavora attualmente presso l'Institut préparatoire aux études d'ingénieur de Kairouan, Università di Kairouan-Tunisia.Si interessa alla preparazione di precursori otticamente attivi da aminoacidi naturali e al loro utilizzo nella sintesi di nuovi eterocicli chirali.