Michael Sheremet, Larysa Sydorchuk, Viktor Shidlovskyi

Nodular forms of goiter with autoimmune thyroiditis, thyroid adenoma

Polymorphic variants of genes BCL-2, CTLA-4, APO-1 / Fas in patients with thyroid pathology regarding its forms.

• Broschiertes Buch

Produktbeschreibung

Abstract To analyze the frequency of polymorphic variants of genes BCL-2, CTLA-4, APO-1 / Fas in patients with thyroid pathology regarding its forms: nodular goiter with autoimmune thyroiditis and thyroid adenoma. Results: Mutation of BCL-2 and CTLA-4 genes in the homozygous state among resident's adult population of Northern Bukovina occurs with a fre-quency 3,2-4,0%, no reliable difference between patients and healthy. Muta-tions of the gene APO-1 / Fas in the homozygous state are not observed. The nature of allelic distribution set: parity ratio between the main A and G minor alleles of the BCL-2 gene. A dominance of wild-allele mutation of the G-allele CTLA-4 gene 2.57 times among patients, and 3.54 times among healthy; and the prevalence of G-allele mutation of the A-allele gene Fas - 9.87 times in pa-tients and 7.33 times - in healthy. Conclusions: Pathology of the thyroid gland in general has unreliable chances to be inherited depending on the polymorphism of BCL-2, CTLA-4and Fas genes in Bukovina (Western Ukraine).

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 64
• Erscheinungstermin: 5. September 2017
• Englisch
• Abmessung: 220mm x 150mm x 4mm
• Gewicht: 113g
• ISBN-13: 9786202027199
• ISBN-10: 6202027193
• Artikelnr.: 49067127

Autorenporträt

Chirurgische Abteilung, ¿1 der Bukowiner Staatlichen Medizinischen Universität. Michael Ivanovich Sheremet, PhD, Assistenzprofessor; Volodymyr Volodymyrovich Tarabanchuk, PhD, Assistenzprofessor;Vitaliy Vasilyovich Maksymyuk, MD, PhD, Professor.