Nonsense Mutation Correction in Human Diseases - Lejeune, Fabrice;Benhabiles, Hana;Jia, Jieshuang
64,99 €
inkl. MwSt.
Versandkostenfrei*
Versandfertig in 6-10 Tagen
payback
32 °P sammeln
  • Broschiertes Buch

Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene, and the presentation of the nonsense-mediated mRNA decay (NMD).
It presents the mechanism of action and rationale associated with each strategy to correct nonsense mutations with the results of clinical trials to further support this basis. In addition, the book shows how it may be possible to combine several of these strategies to…mehr

Andere Kunden interessierten sich auch für
Produktbeschreibung
Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene, and the presentation of the nonsense-mediated mRNA decay (NMD).

It presents the mechanism of action and rationale associated with each strategy to correct nonsense mutations with the results of clinical trials to further support this basis. In addition, the book shows how it may be possible to combine several of these strategies to ultimately improve the efficiency of correction, also suggesting the future goals and objectives to improve treatment modalities in this evolving sphere of personalized medicine.
Autorenporträt
Dr. Fabrice Lejenue studies the mechanisms that regulate or deregulate the quality control of protein synthesis with the aim to one day utilize these mechanisms to chemically treat diseases such as cystic fibrosis, muscular dystrophy and cancer. He studied under Dr. Lynne Maquat, Director, Center for RNA Biology, and the scientist responsible for discovering the control mechanism messenger RNA carrying nonsense mutations in mammals. Dr. Lejeune continues this work at his lab at the Pasteur Institute.

Hana is a PhD student working with Dr. Fabrice Lejeune. She obtained her Master's degree in Genetics, in 2014, at the University of Lille in France. Prior coming to Lille, Hana did a biological engineering degree at Boumerdès University in Algeria. She acquired biomedical and biotechnological knowledge that she applies during her PhD. By coupling her engineering and research training, Hana is currently identifying new drugs correcting a nonsense mutation with a focus on their application in clinics to promote the expression of normally unexpressed proteins in these types of pathologies.
Rezensionen
"Not only is the content well selected and planned, but the language is clear and simple and the illustrations are magnificent.This book is unique - there are no comparable books. The authors have achieved a tremendous goal. Score: 100 - 5 Stars!" --Doody's